摘要
目的:探索高原地区慢性失眠共病阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者的睡眠结构特点。方法:选择来自青海红十字医院睡眠医学科2014年1月至2015年6月生活在高原地区的(以西宁为主,海拔2250 m以上)原发性慢性失眠患者23例[失眠组,年龄(48.2±9.9)岁],慢性失眠共病OSA患者22例[共病组,年龄(46.8±8.9)岁]和正常睡眠者20例[健康组,年龄(46.2±7.1)岁],采用Alice 5进行整夜多导睡眠监测,并按照《美国睡眠医学会睡眠及其相关事件判读手册》对其睡眠结构进行比较,探索慢性失眠共病OSA患者的睡眠结构特点。结果:失眠组和共病组的睡眠效率[(62.4%±16.7%)、(59.8%±16.0%)比(80.9%±8.8%)]、非快速眼动(non-rapid eye movement,NREM)2期睡眠比[(37.9%±12.2%)、(36.2%±12.5%)比(49.7%±6.2%)]和快速眼动(rapid eye movement,REM)期睡眠比[(7.7%±4.0%)、(6.5%±4.0%)比(12.5%±4.6%)]均显著低于健康组(均P<0.05);共病组氧减指数均显著高于失眠组和健康组[(30.8±29.2)比(7.9±7.5)、(5.9±2.7)次/h,均P<0.05],失眠组NREM3潜伏期均显著长于共病组和健康组[(148.9±113.6)比(89.3±51.8)、(59.1±40.3)min,均P<0.05]。结论:高原地区慢性失眠共病OSA患者表现出不同于同地区原发性慢性失眠患者的睡眠结构,其入睡后能更快地进入深度睡眠,且睡眠质量显著低于正常睡眠者。
Objective To explore the characteristics of the sleep structures of patients with both chronic insomnia and obstructive sleep apnea(OSA)in plateau area.Methods Polysomography Alice 5 was applied to 23 patients with primary chronic insomnia[insomnia group,age(48.2±9.9)years],22 patients with both chronic insomnia and OSA[comorbidity group,age(46.8±8.9)years],who both came from Qinghai Red Cross Hospital between January,2014 to June,2015 and 20 subjects with normal sleep[healthy group,age(46.2±7.1)years]in plateau area(mainly in Xining,altitude 2250 meters or above)to compare and explore their sleep structures by the whole night sleep monitoring in the sleep monitoring room.The sleep structures were compared according to the American Academy of Sleep Medicine(AASM)Manual for the Scoring of Sleep and Associated Events.Results Compared to healthy group,insomnia group and comorbidity group both had significantly lower sleep efficiency[(62.4%±16.7%),(59.8%±16.0%)vs(80.9%±8.8%)],non-rapid eye movement(NREM)phase 2 sleep ratio[(37.9%±12.2%),(36.2%±12.5%)vs(49.7%±6.2%)]and rapid eye movement(REM)sleep ratio[(7.7%±4.0%),(6.5%±4.0%)vs(12.5%±4.6%)](all P<0.05);comorbidity group had a significantly higher oxygen desaturation index than insomnia group and healthy group[(30.8±29.2)vs(7.9±7.5),(5.9±2.7)times/h](P<0.05);insomnia group′s sleep latency of NREM3 stage was significantly longer than comorbidity group and healthy group[(148.9±113.6)vs(89.3±51.8),(59.1±40.3)min](both P<0.05).Conclusion Patients with both chronic insomnia and OSA and patients with chronic insomnia only in plateau area have different sleep structures,and both of their sleep quality are lower than the people with normal sleep;patients with both chronic insomnia and OSA could enter deep sleep more quickly after sleep onset.
作者
李琼
郝丽娟
申荷永
安静
冯磊
陈振国
段成民
才昂仁增
Li Qiong;Hao Lijuan;Shen Heyong;An Jing;Feng Lei;Chen Zhenguo;Duan Chengmin;Caiangrenzeng null(Psychology Department,Sichuan Normal University,Chengdu 610000,China;Sleep Medicine Center,Qinghai Red Cross Hospital,Xining 810000,China;Psychology Department,South China Normal University,Guangzhou 510631,China)
出处
《中华健康管理学杂志》
CAS
CSCD
2021年第3期233-236,共4页
Chinese Journal of Health Management
基金
国家自然科学基金(81560021)。
关键词
入睡和睡眠障碍
睡眠呼吸暂停
阻塞性
共病现象
高原地区
Sleep initiation and maintenance disorders
Sleep apnea,obstructive
Comorbidity
Plateau area
