摘要
目的通过文献分析,了解国内5-羟色胺综合征(SS)的临床特点及诊治现状。方法通过数据库检索,对已发表的国内5-羟色胺综合征病案报告文献进行汇总,分析临床特点及治疗转归情况。结果共入选41例患者,最主要症状为血压或心率的升高(97.6%)、大汗(92.7%),其次为震颤(80.5%)、肌阵挛或肌强直(73.2%)、发热(58.6%)、激越或谵妄(61%)、意识障碍(58.5%)等,39例患者转归良好,1例死亡,1例因合并其他疾病死亡。结论选择性5-羟色胺再摄取抑制剂仍是最常见的导致SS的药物,最常见的表现为自主神经系统障碍,其次为神经肌肉症状、精神或意识状态改变。5-羟色胺综合征在国内目前重视度尚不够,早期发现、早期干预对于减少临床不良结局有积极作用。
Objective To explore the clinical features,diagnosis and treatment status of serotonin syndrome(SS)in China by analyzing the case report of serotonin syndrome.Methods We studied all case report of serotonin syndrome by database retrieval.The clinical features,treatment and outcome were analyzed statistically.Results A total of 41 patients with serotonin syndrome were collected,the most common clinical features were the increase of blood pressure or heart rate(97.6%),sweating(92.7%),tremor(80.5%),Secondly were myoclonus or myotonia(73.2%),fever(58.6%),agitation or delirium(61%),and disturbance of consciousness(58.5%).Conclusion Selective 5-hydroxytryptamine reuptake inhibitors are still the most common drugs leading to serotonin syndrome.The most common features were autonomic nervous system disorders,followed by neuromuscular symptoms,mental or consciousness changes.At present,the prevention and diagnosis of serotonin syndrome have not been given enough attention in our country.Early detection and early intervention have a positive effect on reducing the clinical adverse outcome.
作者
吴军
尹长森
汤其强
WU Jun;YIN Changsen;TANG Qiqiang(Department of Geriatrics,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China)
出处
《中风与神经疾病杂志》
CAS
2021年第6期526-529,共4页
Journal of Apoplexy and Nervous Diseases
基金
中国科学院战略性先导科技专项(B类)子课题(No.XDB39040400)。
