摘要
雷公藤是始载于《神农本草经》中的一种传统中药,药用历史悠久,具有祛风除湿、通络止痛、活血消肿的功效。现代药理研究证实其具有抗炎、免疫抑制、抗肿瘤等药理活性,临床上主要用于治疗类风湿性关节炎、紫癜性肾炎、湿疹、银屑病等免疫性疾病,临床疗效独特,其发挥药理作用的机制主要通过调整炎症因子、信号通路等,而其所含的450多种化学成分是其发挥作用的重要物质基础。通过对雷公藤主要化学成分、药理作用及其机制和临床应用3个方面进行了系统的梳理与归纳总结,为雷公藤及其制剂在临床的安全合理应用提供参考依据。
Leigongteng(Tripterygium wilfordii) is a kind of traditional Chinese medicine, which is first recorded in Shennong Bencao Jing and has a long history. It has the functions of eliminating wind and dampness, dredging the collaterals to stop pain promoting blood circulation and relieving edema. Modern pharmacological research has confirmed that it has anti-inflammatory,immunosuppressive,anti-tumor and other pharmacological activities. Clinically,it is mainly used for the treatment of rheumatoid arthritis,purpura nephritis,eczema,psoriasis and other immune diseases,with unique clinical efficacy. The mechanism of its pharmacological action is mainly through the regulation of inflammatory factors,signal pathways and so on,and more than 450 chemical components are the material basis to play an important role. The main chemical components,pharmacologic effect,mechanism and clinical application of Leigongteng( Tripterygium wilfordii) were systematically reviewed and summarized in order to provide reference for the safe and reasonable application of Leigongteng( Tripterygium wilfordii) and its preparations in clinical practice.
作者
康冰亚
赵熙婷
杨亚蕾
孟菲
李春晓
李学林
陈天朝
ANG Bingya;ZHAO Xiting;YANG Yalei;MEGN Fei;LI Chunxiao;LI Xuelin;CHEN Tianchao(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第6期102-106,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家“重大新药创制”科技重大专项(2015ZX09501004-001-007)
河南省中医药科学研究专项(20-21ZY2171)。
关键词
雷公藤
化学成分
药理作用
临床应用
Leigongteng(Tripterygium wilfordii)
chemical constituents
pharmacological action
clinical application
