摘要
Eukaryotic DNA replication is tightly restricted to onlyonce per cell cycle in order to maintain genome stability.Cells use multiple mechanisms to control the assemblyof the prereplication complex (pre-RC), a process knownas replication licensing. This review focuses on theregulation of replication licensing by posttranslationalmodifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RCcomplexes as well as preventing rereplication in each cellcycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussedas well.
