摘要
目的:探讨妊娠合并甲状腺功能减退者血清C-反应蛋白(CRP)、中性粒细胞与淋巴细胞比值(NLR)、胎儿纤维连接蛋白(fFN)、血小板激活因子(PAF)水平及与早产关系。方法:选取本院2018年1月-2019年1月收治的妊娠合并甲状腺功能减退患者151例为观察组,正常妊娠120例为对照组。于妊娠28周检测并比较两组孕妇CRP、NLR、fFN、PAF水平。根据观察组孕妇是否早产分为早产组46例和非早产组105例,采用logistic回归分析影响妊娠合并甲状腺功能减退者早产因素。结果:观察组血清CRP(8.86±2.31 mg/L)、NLR(4.36±1.28)、fFN(40.51±6.51 ng/ml)、PAF(2.89±0.55 ng/ml)水平均高于对照组(5.14±1.66 mg/L、1.77±0.53、28.66±4.49 ng/ml、2.03±0.27 ng/ml)(P<0.05);年龄大、患有阴道炎、宫颈短缩、血清CRP、NLR、fFN、PAF水平高是影响妊娠合并甲状腺功能减退者早产的独立危险因素(P<0.05)。结论:妊娠合并甲状腺功能减退者血清CRP、NLR、PAF、fFN水平明显升高,且水平高是其早产的独立危险因素。
Objective: To investigate the relationship between the levels of serum C-reactive protein(CRP), neutrophil to lymphocyte ratio(NLR), fetal fibronectin(FFN), platelet activating factor(PAF) of the pregnant women with hypothyroidism and the preterm delivery occurrence. Methods: 151 pregnant women with hypothyroidism were enrolled in observation group and 120 healthy pregnant women were enrolled in control group from January 2018 to January 2019. The levels of CRP, NLR, FFN and PAF of the women during the 28 th gestational week were measured and were compared between the two groups. In the observation group, there were 46 women with preterm delivery in group A and 105 women without preterm delivery in group B. Logistic regression was used to analyze the factors affecting preterm delivery of the pregnant women with hypothyroidism. Results: The serum levels of CRP(8.86±2.31 mg/L), NLR(4.36±1.28), FFN(40.51±6.51 ng/ml) and PAF(2.89±0.55 ng/ml) of the women in the observation group were significant higher than those(5.14±1.66 mg/L, 1.77±0.53, 28.66±4.49 ng/ml, and 2.03±0.27 ng/ml) of the women in the control group(P<0.05). Increase of age, vaginitis, cervix shortening, high levels of serum CRP, NLR, FFN and PAF were the independent risk factors of preterm delivery of the pregnant women with hypothyroidism(P<0.05). Conclusion: The levels of serum CRP, NLR, PAF and fFN of the pregnant women with hypothyroidism increase significantly, and the high levels of which are the independent risk factors affecting their preterm delivery occurrence.
作者
王永祥
赵丽杰
马庆良
WANG Yongxiang;ZHAO Lijie;MA Qingliang(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201210)
出处
《中国计划生育学杂志》
2021年第5期935-938,共4页
Chinese Journal of Family Planning
