摘要
目的:考察复方芩兰口服液对甲型流感病毒肺炎、呼吸道合胞病毒肺炎、腺病毒咽炎的药效作用。方法:采用甲型流感病毒(A/FM/1/47(H1N1))感染ICR小鼠肺炎模型,考察复方芩兰口服液对模型小鼠的死亡率、死亡抑制率、平均存活天数及生命延长率的影响,对肺组织及支气管病变的影响,以及对血清免疫因子的影响;采用腺病毒感染ICR小鼠咽炎模型,考察复方芩兰口服液对模型小鼠咽喉部黏膜组织病变的影响;采用呼吸道合胞病毒感染ICR小鼠肺炎模型,考察复方芩兰口服液对模型小鼠肺指数、肺组织及支气管病变、血清免疫因子及肺组织免疫因子的影响。结果:复方芩兰口服液对甲型流感病毒感染有一定的死亡保护作用,治疗给药可以改善肺组织及肺支气管病变、降低血清免疫因子水平;复方芩兰口服液对呼吸道合胞病毒感染有良好的预防作用,治疗给药可以改善肺组织及肺支气管病变、降低血清及肺组织免疫因子水平;复方芩兰口服液对腺病毒引起的咽炎有良好的治疗作用,可以改善咽部病变。结论:复方芩兰口服液对甲型流感病毒肺炎、呼吸道合胞病毒肺炎、腺病毒咽炎均有良好的疗效。
Objective:To investigate the efficacy of compound Qinlan oral liquid on influenza A virus pneumonia,respiratory syncytial virus pneumonia,and adenovirus pharyngitis.Methods:In this study,influenza A virus(A/FM/1/47(H1N1)was used to infect ICR mouse pneumonia models to investigate the mortality,death inhibition rate,average survival days and the average survival time of compound Qinlan oral liquid on model mice,the effect of life extension rate,the effect on lung tissue and bronchial lesions,and the effect on serum immune factors;adenovirus infection ICR mouse pharyngitis model was used to investigate the effect of compound Qinlan oral liquid on the mucosal tissue lesions of the throat of the model mice;Using respiratory syncytial virus infection ICR mouse pneumonia model to investigate the effects of compound Qinlan Oral Liquid on lung index,lung tissue and bronchial disease,serum immune factors and lung tissue immune factors in model mice.Results:The results of the study indicated that compound Qinlan Oral Liquid had a certain death protection effect against influenza A virus infection.Therapeutic administration can improve lung tissue and lung bronchial diseases,and reduce serum immune factor content;compound Qinlan Oral Liquid had a beneficial effect on the respiratory tract.Cytovirus infection has a good preventive effect.Therapeutic administration can improve lung tissue and lung bronchial disease,reduce serum and lung tissue immune factor content;compound Qinlan Oral Liquid had a good therapeutic effect on adenovirus-induced pharyngitis,and can improve the pharynx Department of disease.Conclusion:Compound Qinlan Oral Liquid has a good effect on influenza A virus pneumonia,respiratory syncytial virus pneumonia,and adenovirus pharyngitis.
作者
鲍岩岩
高英杰
周利润
耿子涵
姚荣妹
韩冰
葛一蒙
崔晓兰
时宇静
BAO Yanyan;GAO Yingjie;ZHOU Lirun;GENG Zihan;YAO Rongmei;HAN Bing;GE Yimeng;CUI Xiaolan;SHI Yujing(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Heilongjiang ZBD Pharmaceutical Co.,Ltd.,Hulin 158400,China)
出处
《世界中医药》
CAS
2021年第12期1809-1817,共9页
World Chinese Medicine
基金
国家自然科学基金面上项目(81873072)
中国中医科学院中医药防治流感技术体系项目(ZZ13-035-09)
中国中医科学院育苗基金培育专项(ZZ11-093)
中国中医科学院自主课题项目(ZXKT17037)。
关键词
复方芩兰口服液
甲型流感病毒
呼吸道合胞病毒
腺病毒
药效作用
肺炎
咽炎
免疫因子
Compound Qinlan Oral Liquid
Influenza A virus
Respiratory syncytial virus
Adenovirus
Efficacy
Pneumonia
Pharyngitis
Immune factor
