摘要
目的:分析腹腔镜卵巢良性囊肿剥除术对患者性激素水平及免疫功能的影响。方法:选取2018年3月-2020年3月本院收治的良性卵巢囊肿患者114例,按随机数字表法分为腹腔镜组(57例)和开腹组(57例)。开腹组予以开腹卵巢囊肿剥除术治疗,记录两组手术指标,比较两组术前、术后1、3个月性激素水平及术前、出院时免疫功能指标及住院期间并发症发生情况。结果:腹腔镜组术中出血量(35.5±6.9ml)低于开腹组,手术时间(54.4±3.1min)、肛门排气时间(16.7±1.3h)及术后下床时间(30.2±1.3h)均短于开腹组(P<0.05)。术后1、3个月,两组血清雌二醇(E2)、抗苗勒管激素(AMH)水平均低于术前,术后3个月两组血清E2、AMH水平低于术后1个月但腹腔镜组高于开腹组(均P<0.05);术后1、3个月,两组血清卵泡刺激素(FSH)、促黄体激素(LH)水平高于术前,但腹腔镜组低于开腹组(P<0.05);术后3个月腹腔镜组血清FSH、LH水平低于术后1个月(P<0.05)。出院时两组血清免疫球蛋白G水平高于术前且腹腔镜组高于开腹组(P<0.05);两组血清免疫球蛋白A、免疫球蛋白M水平无差异(P>0.05)。住院期间,腹腔镜组并发症发生率(5.3%)低于开腹组(17.5%)(P<0.05)。结论:气腹式腹腔镜卵巢囊肿剥除术对良性卵巢囊肿患者卵巢功能及免疫功能影响较小,且减少术中出血量,降低术后并发症发生率,利于患者术后康复。
Objective: To analyze the effect of pneumoperitoneum laparoscopic oophorocystectomy for treating patients with benign ovarian cyst on their sex hormone level and immune function. Methods: 114 patients with benign ovarian cyst were randomly divided into the pneumoperitoneal laparoscopic group A(57 patients with pneumoperitoneal laparoscopic oophorocystectomy) and group B(57 patients with laparotomy oophorocystectomy) according to the random number table method from March 2018 to March 2020. The patients in both groups were followed up to discharged from hospital. The operation indexes of the patients in the two groups were recorded. The levels of sex hormone before operation and 1 and 3 months after operation, and the values of immune functions indexes before operation and at the time of discharge from hospital of the patients were compared between the two groups. The complications during hospitalization of the patients in the two groups were observed. Results: The amount of intraoperative blood loss(35.5±6.9 ml) of the patients in group A was significant lower than that of the patients in group B, and the time of operation(54.4±3.1 min), the anal exhaust time(16.7±1.3 h), and the time of postoperative getting out of bed(30.2±1.3 h) of the patients in group A were significant shorter than those of the patients in group B(P<0.05). 1 and 3 months after surgery, the serum levels of estradiol(E2) and anti-mullerin hormone(AMH) of the patients in both groups were significant lower than those before surgery. 3 months after surgery, the serum E2 and AMH levels of the patients in both groups were significant lower than those of the patients 1 month after surgery, but those of the patients in group A were significant higher than those of the patients in group B(all P<0.05).1 and 3 months after operation,the serum levels of follicle stimulating hormone(FSH)and luteinizing hormone(LH)of the patients in the two groups were significant higher than those before operation,but those of the patients in group A were significant lower than those of the patients in group B(P<0.05).The serum levels of FSH and LH of the patients in group A 3 months after surgery were significant lower than those 1 month after surgery(P<0.05).The level of serum immunoglobulin G of the patients in group A was significant higher than that of the patients in group B(P<0.05).There was no significant differences in serum immunoglobulin A and immunoglobulin M levels of the patients between the two groups(P>0.05).During hospitalization,the incidence of complications(5.3%)of the patients in group A was significant lower than that(17.5%)of the patients in group B(P<0.05).Conclusion:The pneumoperitoneum laparoscopic oophorocystectomy has less influence on ovarian function and immune function of the patients with benign ovarian cyst,which can reduce intraoperative blood loss and postoperative complication rate,and is helpful to the postoperative rehabilitation of the patients.
作者
蔡军波
方芳
潘丹
CAI Junbo;FANG Fang;PAN Dan(Taizhou Municipal Hospital,Zhejiang Province,318000)
出处
《中国计划生育学杂志》
2021年第6期1141-1145,共5页
Chinese Journal of Family Planning
关键词
良性卵巢囊肿
卵巢囊肿剥除术
腹腔镜
性激素
免疫功能
并发症
Benign ovarian cyst
Oophorocystectomy
Pneumoperitoneum laparoscopic surgery
Sex hormone
Immune function
Complication
