摘要
4D打印是一项能够在特定刺激下使智能材料发生形变的现代化制造技术,该技术以计算机学和材料学为支撑点,将物理学、生物工程学和医学等学科与制造业相结合,并通过逐层添加智能材料的方式制造出三维实体物品。与3D打印相比,4D打印以功能需求为导向,智能材料所形成的几何结构在温度、水等特定刺激作用下可发生折叠、弯曲、膨胀或收缩并形成最终结构,进而实现物品自身性能如硬度、刚度、渗透性等的改变。作为一种数字化智能制造的新方式,4D打印在医学应用中强调人体组织的动态愈合和再生过程,能够有效地实现组织自我修复,完成由结构到功能的仿生,因此可更加真实地模拟人体微环境的动态演变。该文基于国内外4D打印在医学中应用的最新案例,分析其潜在的优势与困境,并对其发展趋势和应用前景进行展望。
4D printing,which distorts smart materials under specific stimulation,is emerging as a kind of modern fabrication technology.Underpinned by computer science and materialogy,4D printing combines a wide range of disciplines including physics,bioengineering,medicine with manufacturing industry,and creates three-dimensional solid objects by adding smart materials layer by layer.Compared with 3D printing,4D printing is functional demand-oriented,and the geometric structure formed by intelligent materials folds,bends,expands or shrinks under specific stimuli such as temperature and water,thus realizing the change of the performance of the object itself,such as hardness,stiffness,permeability and so on.4D printing would serve as a new way of digital intelligent manufacturing,which emphasizes the need to consider the dynamic tissue healing and regeneration processes within human body.In addition,it can effectively realize the self-repair of the tissue and complete the bionics from structure to function,so it more truly simulates the dynamic evolution of human micro-environment.In this review,we collect the latest cases of 4D printing in biomedicines at home and abroad and then the potential advantages and challenges of 4D printing in practical application will be analyzed.Finally,we propose future directions and perspectives to further promote intelligentized 4D bioprinting technology in imitating architectures and function of native human tissues.
作者
党竞医
朱东泽
刘鑫成
孙立国
张煜珅
张昭
范宏斌
Dang Jing-Yi;Zhu Dong-Ze;Liu Xin-Cheng;Sun Li-Guo;Zhang Yu-Shen;Zhang Zhao;Fan Hong-Bin(Department of Orthopedic Surgery,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2021年第6期598-602,共5页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金(31971272)
国家重点研发计划(2016YFB1101104)
陕西省重点研发计划(2018ZDXM-SF-075)。
关键词
4D打印
智能制造
医学应用
4D printing
intelligent manufacturing
medical application
