摘要
子宫内膜容受性在胚胎着床中起重要作用。子宫内膜损伤所致的宫腔粘连是子宫性不孕的常见原因。对子宫内膜容受性的影响除了引起内膜及宫腔的形态结构改变,还从分子生物学方面影响相关因子的表达。宫腔粘连的治疗采用以手术为主的综合治疗方案,对重塑内膜和宫腔的形态有一定的效果,但患者的妊娠率及活产率仍不理想。近年来,改善子宫内膜容受性进而达到功能性修复子宫内膜越来越成为研究的焦点,并且已有研究取得初步进展。本文从形态学和分子生物学水平阐述宫腔粘连对子宫内膜容受性的影响,并在此基础上对相关治疗进展进行综述。
Endometrial receptivity plays an important role in embryo implantation.Intrauterine adhesions induced by endometrial damage are a common cause of uterine infertility.The influence on endometrial receptivity includes not only the changes in the morphology and structure of endometrium,but also the expression of related factors of molecular biology.The comprehensive treatment of intrauterine adhesions based on surgery has a certain effect on remodeling the endometrium and the morphology of the uterine cavity,however,the pregnancy rate and live birth rate are both still unsatisfactory.Recently,improving endometrial receptivity to achieve functional repair of endometrium has become the focus of research,and some progress has been made.This article reviews the influence of intrauterine adhesions on endometrial receptivity and the progress of related treatment.
作者
常亚楠
段华
Chang Yanan;Duan Hua(Department of Minimally Invasive Gynecology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100006,China)
出处
《中华生殖与避孕杂志》
CSCD
北大核心
2021年第5期408-412,共5页
Chinese Journal of Reproduction and Contraception
基金
国家重点研发计划(2018YFC1004803)。
关键词
宫腔粘连
子宫内膜容受性
治疗
Intrauterine adhesions
Endometrial receptivity
Treatment
