摘要
阿尔兹海默症(AD)已成为严重危害人类健康的重大神经退行性疾病,因其发病机制尚未完全阐明,目前仍没有良好的临床治疗药物。随着系统生物学的发展,更多的发病机制不断被提出,为抗AD药物的研发提供了理论支持。本文作者对胆碱能损伤学说、Aβ学说、tau蛋白学说、炎症学说、兴奋性神经损伤学说、“微生物-脑-肠轴”学说等发病机制及临床相关药物的研究进展进行综述,旨在为抗AD药物的研发提供参考。
Alzheimer's disease(AD)has become a major neurodegenerative disease that seriously endangers human health.Because its pathogenesis has not been fully elucidated,there is yet no ideal clinical drug for effective treatment.With the development of systematic biology,more and more pathogeneses have been proposed,which offer the theoretical supports for the research and development of anti-AD drugs.This paper reviews the research progress of popular pathogenesis,such as cholinergic injury theory,Aβtheory,tau protein theory,inflammation theory,excitatory nerve injury theory,“microorganism-brain-gut axis”theory,and related clinical drugs as well,in order to provide a reference for the research of anti-AD drugs.
作者
张雷
范占芳
张作鹏
程卯生
刘洋
ZHANG Lei;FAN Zhan-fang;ZHANG Zuo-peng;CHENG Mao-sheng;LIU Yang(Key Laboratory of Structure-Based Drugs Design and Discovery(Shenyang Pharmaceutical University),Ministry of Education,Shenyang 110016,China)
出处
《中国药物化学杂志》
CAS
CSCD
2021年第6期438-446,469,共10页
Chinese Journal of Medicinal Chemistry
基金
辽宁省高等学校创新人才支持计划项目(LR2017043)。
关键词
阿尔兹海默症
发病机制
临床药物
研究进展
Alzheimer's disease
pathogenesis
clinical drugs
research progress
