摘要
目的探讨百令片联合依帕司他治疗2型糖尿病周围神经病变(DPN)患者临床效果及对氧化应激、炎症反应影响。方法选取2019年2月-2020年6月收治的2型DPN 80例,根据治疗方法不同将其分为试验组和对照组两组各40例。试验组在常规治疗基础上给予百令片联合依帕司他治疗,对照组在常规治疗基础上给予依帕司他治疗。两组均连续治疗4周。观察比较两组治疗前后神经传导速度、密歇根神经病变筛选法(MNSI)评分、氧化应激指标和炎性因子,以及治疗安全性。结果治疗前,两组神经传导速度、MNSI评分、氧化应激指标和炎性因子比较差异均无统计学意义(P>0.05)。治疗后,胫后神经、腓总神经和正中神经运动神经传导速度和感觉神经传导速度两组均快于治疗前,试验组均快于对照组;MNSI评分两组均低于治疗前,且试验组低于对照组;两组血清丙二醛(MDA)水平较治疗前降低,血清超氧化物歧化酶(SOD)水平较治疗前升高,试验组血清MDA水平低于对照组,血清SOD水平高于对照组;血清白细胞介素-6、肿瘤坏死因子-α和超敏C反应蛋白水平两组均较治疗前降低,试验组均低于对照组,差异有统计学意义(P<0.05)。治疗前后,两组血红蛋白、丙氨酸转氨酶和肌酐水平比较差异均无统计学意义(P>0.05)。结论百令片联合依帕司他治疗2型DPN可以通过减少氧化应激反应和炎症反应,改善患者病情,加快神经传导速度,且安全性较好。
Objective To explore clinical efficacy of Bailing Tablets combined with Epalrestat in treatment of patients with type 2 diabetic peripheral neuropathy(DPN)and its effects on oxidative stress and inflammatory reaction.Methods A total of 80 patients with type 2 DPN admitted between February 2019 and June 2020 were selected and divided into experimental group(n=40)and control group(n=40)according to different treatment methods.Experimental group was treated with Bailing Tablets combined with Epalrestat on the basis of conventional treatment,while control group was treated with Epalrestat on the basis of conventional treatment.Both groups were continuously treated for 4 weeks.Values of nerve conduction velocity,Michigan Neuropathy Screening Instrument(MNSI)score,oxidative stress indicators,inflammatory factors and therapeutic safety before and after treatment were observed and compared between two groups.Results Before treatment,there were no significant differences in values of nerve conduction velocity,MNSI score,oxidative stress indicators and inflammatory factors between two groups(P>0.05).After treatment,values of motor nerve conduction velocity and sensory nerve conduction velocity of the posterior tibial nerve,common peroneal nerve and median nerve were significantly faster than those before treatment,which in experimental group were significantly faster than those in control group;MNSI scores were significantly lower than those before treatment in both groups,and the score in experimental group was significantly lower than that in control group;serum malondialdehyde(MDA)levels were significantly lower,while serum superoxide dismutase(SOD)levels were significantly higher than those before treatment in both groups,and serum MDA level in experimental group was significantly lower than that in control group,while serum SOD level in experimental group was significantly higher than that in control group;serum levels of interleukin-6,tumor necrosis factor-αand high-sensitivity C-reactive protein(hs-CRP)were significantly lower than those before treatment in both groups,and the levels in experimental group were significantly lower than those in control group(P<0.05).There were no significant differences in levels of hemoglobin,alanine aminotransferase and creatinine before and after treatment between two groups(P>0.05).Conclusion Bailing Tablets combined with Epalrestat in treatment of patients with type 2 DPN may improve patients'conditions and speed up nerve conductive velocity with good safety by reducing oxidative stress response and inflammatory reaction.
作者
周亚男
杨洁
王丽晖
张金成
吴学伦
魏静
吴岩
马晓华
ZHOU Ya-nan;YANG Jie;WANG Li-hui;ZHANG Jin-cheng;WU Xue-lun;WEI Jing;WU Yan;MA Xiao-hua(The First Department of Endocrinology and Diabetes,the Central Hospital of Cangzhou City,Cangzhou,Hebei 061001,China;Department of Emergency Medicine,the Central Hospital of Cangzhou City,Cangzhou,Hebei 061001,China)
出处
《临床误诊误治》
CAS
2021年第7期29-33,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省医学科学研究重点课题计划(20181532)
沧州市科技计划自筹经费项目(183302091)。
