摘要
小分子荧光探针以其灵敏度高、特异性强、稳定性好、操作便捷和成本低等特点在生命科学、医药化学和环境科学等领域得到了广泛的应用。在农药化学领域,小分子荧光探针常被用作农药残留及重金属污染的检测手段。近年来随着全球开发绿色农药战略需求的不断增强,作为靶向型药物设计和高通量筛选的重要分子工具,荧光探针在绿色农药新产品研发领域的应用不断普及和深化。本文从探针分子的化学设计、靶点识别及药物筛选的角度出发,围绕不同类型的绿色农药重要生物靶点,综述了小分子荧光探针在绿色农药开发领域的研究现状,并对其未来的发展趋势和应用前景进行了展望。
Small-molecule fluorescent probes are widely applied in the fields of life science,medicinal chemistry and environmental science,due to their characteristics of high sensitivity and specificity,good stability and economic applicability.In pesticide chemistry,small-molecule fluorescent probes are frequently utilized in the detection of pesticide residues and heavy metal pollutions.With global strategic needs and rapid technological progress in green pesticide development,fluorescent probes are urgently desired as important molecular tools for design,screening and development of environmentally benign agrichemicals.This article aims to review the key updates of small-molecule fluorescent bioprobes in green pesticide R&D by covering their chemical design,molecular targeting,and screening mechanisms against different green pesticide biotargets,and to provide the current status on their research and application as well as future perspectives.
作者
侯晓涵
刘胜男
高清志
Xiaohan Hou;Shengnan Liu;Qingzhi Gao(School of Pharmaceutical Science and Technology,Tianjin Key Laboratory for Modem Drug Delivery&High-Efficiency,Tianjin University,Tianjin 300072,China;Institute of Molecular Plus,Tianjin University,Tianjin 300072,China)
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2021年第6期1035-1043,共9页
Progress in Chemistry
基金
国家重点研发计划项目(2017YFD0201403)资助。
关键词
小分子荧光探针
绿色农药
鱼尼丁受体
几丁质酶
高通量筛选
small-molecule fluorescent probe
green pesticides
ryanodine receptor
chitin synthase
high-throughput screening
