摘要
目的观察足三里穴位注射生理盐水对脓毒症患者免疫指标的影响。方法选取2019年12月—2021年1月入住广州中医药大学顺德医院重症监护室(ICU)的40例脓毒症患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组各20例。两组患者均按照脓毒症指南给予规范治疗,观察组在对照组基础上应用生理盐水进行足三里穴位注射,每天1次,治疗7 d。比较两组患者治疗前后的白细胞计数(WBC)、淋巴细胞绝对值(LYM);比较两组患者治疗前后的免疫指标[总T细胞数(CD3^(+))、辅助性T细胞数(CD4^(+))、辅助性T细胞数与抑制性T细胞数之比(CD4^(+)/CD8^(+))]及急性生理学和慢性健康状况评分系统Ⅱ(APACHEⅡ)评分;比较两组患者的转归情况。结果两组患者治疗7 d后的LYM、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均高于治疗前,差异有统计学意义(P<0.05);且观察组患者治疗7 d后的LYM、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05);两组患者治疗7 d后的WBC、APACHEⅡ评分低于治疗前,差异有统计学意义(P<0.05);两组患者治疗7 d后的WBC、APACHEⅡ评分比较,差异无统计学意义(P>0.05);两组的28 d死亡率比较,差异无统计学意义(P>0.05)。结论生理盐水足三里穴位注射能改善脓毒症患者免疫指标,在脓毒症治疗中有一定应用价值。
Objective To observe the effect of normal saline injection at zusanli acupoint on immune indexes of patients with sepsis.Methods A total of 40 sepsis patients admitted to the intensive care unit(ICU)of Shunde Hospital of Guangzhou University of Traditional Chinese Medicine from December 2019 to January 2021 were selected as the research subjects.They were divided into observation group and control group by random number table method,with 20 patients in each group.All the patients were given standard treatment according to sepsis guidelines,the observation group was injected with normal saline at zusanli acupoint once a day for 7 days on the basis of control group.The white blood cell count(WBC)and absolute lymphocyte value(LYM)of two groups were compared before and after treatment.Immune indexes(total number of T cells[CD3^(+)],number of helper T cells[CD4^(+)],ratio of helper T cells to inhibitory T cells[CD4^(+)/CD8^(+)]),acute physiology and chronic health status scoring systemⅡ(APACHEⅡ)scores were compared between two groups before and after treatment.The outcomes of the two groups were compared.Results The levels of LYM,CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups after 7 d of treatment were higher than those before treatment,with statistically significant differences(P<0.05).LYM,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)after 7 days of treatment in observation group were higher than those in control group,with statistically significant differences(P<0.05).The WBC and APACHEⅡscores of the two groups after 7 d of treatment were lower than those before treatment,with statistically significant differences(P<0.05).There were no significant differences in WBC and APACHEⅡscores between the two groups after 7 days of treatment(P>0.05).There was no significant difference in 28-day mortality between the two groups(P>0.05).Conclusion Zusanli acupoint injection of normal saline can improve the immune indexes of patients with sepsis,and it has certain application value in the treatment of sepsis.
作者
魏清兰
刘凌凌
朱满桂
钟建
WEI Qing-lan;LIU Ling-ling;ZHU Man-gui;ZHONG Jian(Department of Critical Care Medicine,Shunde Hospital of Guangzhou University of Traditional Chinese Medicine,Guangdong Province,Shunde,528300,China)
出处
《中国当代医药》
CAS
2021年第20期51-54,共4页
China Modern Medicine
基金
广东省佛山市科技创新项目自筹经费类科技计划项目(1920001001588)。
关键词
穴位注射
足三里
脓毒症
重症监护室
免疫
Acupoint injection
Zusanli
Sepsis
Intensive care unit
Immunity
