摘要
目的探讨布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床效果。方法选取2018年1月—2019年12月辽宁省健康产业集团铁煤总医院收治的100例慢性阻塞性肺疾病急性加重患者作为研究对象,采用随机数字表法将其分为对照组(50例)和观察组(50例)。对照组患者采取盐酸氨溴索方法治疗,观察组患者在对照组基础上增加布地奈德雾化吸入治疗。比较两组患者的临床症状缓解时间、肺功能指标、动脉血氧指标以及治疗总有效率。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的第1秒用力呼吸量(FEV1)、最大肺活量(FVC)、呼吸流量峰值(PEF)均高于对照组,差异有统计学意义(P<0.05);观察组患者的慢性阻塞性肺疾病症状(CAT)评分低于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的动脉血氧分压(PaO2)高于对照组,差异有统计学意义(P<0.05);观察组患者的动脉二氧化碳分压(PaCO2)低于对照组,差异有统计学意义(P<0.05);观察组患者的喘憋缓解时间、啰音消失时间、咳嗽缓解时间均短于对照组,差异有统计学意义(P<0.05)。结论布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期的临床效果较好,能有效提高患者的治疗有效率,改善患者的肺功能指标和动脉血氧指标,缩短临床症状缓解时间,具有重要的临床研究价值。
Objective To investigate the clinical effect of nebulized inhalation of Budesonide in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods From January 2018 to December 2019,100 patients with acute exacerbation of chronic obstructive pulmonary disease in Liaoning Health Industry Group Iron Coal General Hospital were selected as subjects.The patients were divided into control group(50 cases)and observation group(50 cases)by random number table method.Ambroxol Hydrochloride was given in the control group,and on the basis of control group,observation group was additionally treated with nebulized inhalation of Budesonide.The clinical symptom remission time,pulmonary function indexes,arterial oxygen indexes and the total effective rate of treatment were compared between the two groups.Results The total effective rate of observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),and peak expiratory flow(PEF)of the observation group were higher than those in the control group,the differences were statistically significant(P<0.05);and the symptoms of chronic obstructive pulmonary disease(CAT)score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).After treatment,the arterial partial pressure of oxygen(PaO2)in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The arterial partial pressure of carbon dioxide(PaCO2)in observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The asthma relief time,rale disappearance time and cough relief time in observation group were all shorter than those in the control group,with statistically significant differences(P<0.05).Conclusion Nebulized inhalation of Budesonide has a good clinical effect in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can effectively improve the treatment efficiency of patients,improve the pulmonary function indexes and arterial oxygen indexes of patients,and shorten the remission time of clinical symptoms,which has important clinical research value.
作者
林大永
LIN Da-yong(Department of Respiratory Medicine,Liaoning Health Industry Group Iron Coal General Hospital,Liaoning Province,Diaobingshan112700,China)
出处
《中国当代医药》
CAS
2021年第20期76-78,82,共4页
China Modern Medicine
关键词
布地奈德雾化吸入
慢性阻塞性肺疾病急性加重
临床效果
盐酸氨溴索
呼吸衰竭
复方异丙托溴铵
Nebulized inhalation of Budesonide
Acute exacerbation of chronic obstructive pulmonary disease
Clinical effect
Ambroxol Hydrochloride
Respiratory failure
Ipratropium Bromide
