摘要
目的探讨骨钙素(BGP)、β胶原特殊序列(β-Crosslaps)及总Ⅰ型前胶原氨基端肽(t-P1NP)在骨质疏松性骨折风险中的评价作用。方法选择2019年1月至2020年6月由该院诊治的骨质疏松患者93例为骨质疏松组,选择同期50例无骨质疏松者为对照组,比较两组骨钙素、β胶原特殊序列及t-P1NP水平;并根据骨折风险评价工具(FRAX)评价结果,将骨质疏松组患者分为易骨折组与不易骨折组,比较两组骨钙素、β-Crosslaps及t-P1NP水平,用Speaman相关性分析BGP、β-Crosslaps及t-P1NP水平与骨质疏松性骨折风险相关性,并采用ROC曲线分析BGP、β-Crosslaps及t-P1NP对骨质疏松性骨折风险预测价值。结果骨质疏松组患者BGP水平低于对照组差异有统计学意义(P<0.05),β-Crosslaps与t-P1NP水平高于对照组,差异有统计学意义(P<0.05)。根据FRAX评价93例患者中有9例患者易发生骨折占9.68%,84例患者不易发生骨折占90.32%;易骨折组BGP水平低于不易骨折组,差异有统计学意义(P<0.05),β-Crosslaps与t-P1NP水平高于不易骨折组,差异有统计学意义(P<0.05)。β-Crosslaps及t-P1NP水平与骨质疏松性骨折风险呈正相关关系,与BGP水平呈负相关关系(r=-0.652,P<0.05)。β-Crosslaps的ROC曲线对骨质疏松骨折风险预测价值最高,其次是t-P1NP、BGP(均P<0.05)。结论BGP、β-Crosslaps、t-P1NP可早期判断骨质疏松患者发生骨折风险,且血清β-Crosslaps、t-P1NP水平越高,BGP水平越低,则患者发生骨折风险越高。
Objective To investigate role of osteocalcin(boneglaprotein,BGP),β-crosslaps(β-Crosslaps)and total procollagen type 1 amino-terminal propeptide(t-P1NP)in evaluating the risk of osteoporotic fracture.Methods Ninety-three patients with osteoporosis and 50 patients free from osteoporosis in our hospital from January 2019 to June 2020 were enrolled,and set as osteoporosis group and control group,respectively.Osteoporosis group was further divided into subgroups according to the fracture risk assessment tool(FRAX),fracture-prone group and non-fracture group.BGP,β-crosslaps and t-P1NP levels were detected and compared between two groups and two subgroups.Speaman correlation was used to analyze the correlation between the levels of BGP,β-crosslaps and t-P1NP and the risk of osteoporotic fracture,and the ROC curve was used to analyze the predictive value of BGP,β-crosslaps and t-P1NP on the risk of osteoporotic fracture.Results The level of BGP in the osteoporosis group was lower than that in the control group,the difference was statistically significant(P<0.05),and the levels ofβ-CrossLaps and t-P1NP in the osteoporosis group were higher than those in the control group,the difference was statistically significant(P<0.05).According to FRAX evaluation,9 of 93 patients were prone to fracture,accounting for 9.68%,84 patients were not prone to fracture,accounting for 90.32%;the level of BGP in easy fracture group was lower than that in non easy fracture group,the difference was statistically significant(P<0.05),the level ofβ-CrossLaps and t-P1NP in easy fracture group was higher than that in non easy fracture group,the difference was statistically significant(P<0.05).The levels ofβ-CrossLaps and t-P1NP were positively correlated with the risk of osteoporotic fracture,and negatively correlated with the level of BGP,the difference was statistically significant(r=-0.652,P<0.05).The ROC curve ofβ-CrossLaps had the highest predictive value for osteoporotic fracture risk,followed by t-P1NP and BGP,the differences were statistically significant(all P<0.05).Conclusion BGP,β-crosslaps and t-P1NP can be used to determine the risk of fracture in patients with osteoporosis.The higher the serum levels ofβ-crosslaps and t-P1NP,the lower the BGP level,the higher the risk of fracture.
作者
郭莉
邹明
朱义芳
池继敏
黄玉霞
GUO Li;ZOU Ming;ZHU Yifang;CHI Jimin;HUANG Yuxia(Department of Clinical Laboratory,Sichuan Orthopaedic Hospital,Chengdu,Sichuan 610041,China)
出处
《国际检验医学杂志》
CAS
2021年第14期1769-1772,共4页
International Journal of Laboratory Medicine
