摘要
1例78岁男性患者,诊断为脑卒中后癫痫。2020年7月19日给予丙戊酸钠缓释片(0.5 g,bid)抗癫痫治疗。8月20日因抽搐再次发作,自行调整丙戊酸钠用量为2 g,bid,2 d后出现抽搐频繁发作及乳酸、血氨升高。入院后考虑丙戊酸钠过量致高氨血症脑病可能性大,立即停用丙戊酸钠,同时给予降血氨对症治疗,调整抗癫痫药物为左乙拉西坦片(0.5 g,bid)联合奥卡西平片(0.3 g,qd)。2 d后患者症状好转,抽搐未再发作。
A 78-year-old male patient diagnosed with post-stroke epilepsy was treated with sodium valproate sustained-release tablets(0.5 g,bid)since July 19th,2020.On August 20th,the dose of sodium valproate was increased to 2 g,bid by himself because of another attack of seizures.He developed frequent attack of seizures,high lactic acid and blood ammonia 2 days later.After admission,hyperammonemia encephalopathy caused by overdose of sodium valproate were highly suspected.Sodium valproate was stopped immediately and levetiracetam tablets(0.5 g,bid)combined with oxcarbazepine tablets(0.3 g,qd),symptomatic treatments such as decreasing blood ammonia were given to him.The symptoms improved after 2 days and the seizure did not recur.
作者
崔海珍
王华
CUI Hai-zhen;WANG Hua(Department of Pharmacy,China-Japan Union Hospital of Jilin University,Changchun 130033,China)
出处
《中国药物应用与监测》
CAS
2021年第3期204-206,共3页
Chinese Journal of Drug Application and Monitoring
基金
吉林省药品再评价协会项目[(2019)科技字(1870)号]。
关键词
丙戊酸钠
癫痫
高氨血症脑病
药品不良反应
Sodium valproate
Epilepsy
Hyperammonemia encephalopathy
Adverse drug reaction
