摘要
目的:探讨川崎病(KD)患儿急性期心型脂肪酸结合蛋白(h-FABP)、血小板膜糖蛋白Ⅱb/Ⅲa纤维蛋白原受体(PAC-1)表达与冠状动脉受损的关系。方法:选取2017年1月—2019年8月治疗的KD患儿101例(观察组),其中有冠状动脉损伤者48例,同时选取健康儿童60名作为对照组,采用酶联免疫吸附法检测血清h-FABP水平,采用流式细胞仪检测PAC-1表达。结果:观察组血清h-FABP、PAC-1表达水平分别为(19.94±4.03)ng/mL和(6.44±1.12)%,明显高于对照组(均P<0.05);观察组有冠状动脉损伤患儿血清h-FABP、PAC-1表达水平分别为(20.12±3.32)ng/mL和(6.94±1.06)%,明显高于无冠状动脉损伤患儿(均P<0.05);观察组重度冠状动脉损伤患儿血清h-FABP、PAC-1表达水平分别为(18.22±2.19)ng/mL和(6.22±1.00)%,明显高于轻中度患儿(均P<0.05);观察组血清h-FABP、PAC-1与D-D呈正相关性(r=0.433和0.501,均P<0.05);血清h-FABP、PAC-1诊断有无冠状动脉损伤的ROC曲线下面积分别为0.801和0.779(P<0.05),截断值分别为18.50 ng/mL和6.10%,灵敏性分别为80.50%和77.80%,特异性分别为78.00%和70.00%。结论:KD患儿急性期h-FABP、PAC-1表达升高,与患儿冠状动脉受损有关。
Objective:To investigate the relationship between the expression of heart-type fatty acid binding protein(h-FABP),platelet membrane glycoproteinⅡb/Ⅲa fibrinogen receptor(PAC-1)and coronary artery damage and cardiac function in children with Kawasaki disease(KD).Methods:A total of 101 children with KD(observation group)treated from January 2017 to August 2019 were selected,including 48 cases with coronary artery injury,and 60 healthy children were selected as control group,the serum h-FABP level was detected by ELISA,PAC-1 expression was detected by flow cytometry.Results:The expression levels of serum h-FABP and PAC-1 in the observation group were(19.94±4.03)ng/mL and(6.44±1.12)%,which were significantly higher than those in the control group(all P<0.05).The expression levels of serum h-FABP and PAC-1 in the observation group were(20.12±3.32)ng/mL and(6.94±1.06)%,which were significantly higher than those in the non-coronary injury group(all P<0.05).The levels of serum H-FABP and PAC-1 inchildren with severe coronary injury of the observation group were(18.22±2.19)ng/mL and(6.22±1.00)%,which were significantly higher than those in the mild to moderate group(all P<0.05);in the observation group,serum h-FABP and PAC-1 were positively correlated with D-D(r=0.433 and 0.501,all P<0.05);the area under the ROC curve of serum h-FABP and PAC-1 for diagnosis of coronary artery injury was 0.801 and 0.779(all P<0.05),the cutoff values were 18.50 ng/mL and 6.10%,the sensitivity was 80.50% and 77.80%,and the specificity was 78.00% and 70.00%,respectively.Conclusion:The expression of h-FABP and PAC-1 increase in KD children in acute phase,which are related to the impairment of coronary artery.
作者
贾丽娟
吕爱婷
冯迎军
王芳洁
孙琪青
JIALi-juan;LyuAi-ting;FENGYing-jun;WANGFang-jie;SunQi-qing(Department of Cardiovascular Internal Medicine,Children′s Hospital Affiliated to Zhengzhou University,Henan Children′s Hospital,Zhengzhou Children′s Hospital,Zhengzhou 450000,China)
出处
《天津医科大学学报》
2021年第4期334-337,共4页
Journal of Tianjin Medical University
基金
河南省医学科技攻关计划(2018020695)。
