摘要
目的探讨肺泡一氧化氮测定(CaNO)在哮喘患者中的临床意义。方法将2020年1-7月就诊于该院门诊存在咳嗽、呼吸困难症状超过3周或有哮喘病史的患者,前瞻性行口呼气一氧化氮测定和肺功能检查,分为哮喘组和非哮喘组,比较两组CaNO、支气管树的NO浓度(FeNO)与肺功能指标的关系。结果共纳入研究对象196例,其中男88例(44.9%),女108例(55.1%),哮喘组115例(58.7%),非哮喘组81例(41.3%),两组一般资料比较差异无统计学意义(P>0.05)。哮喘组FeNO(45.99±30.63)ppb高于非哮喘组(18.98±7.91)ppb,差异有统计学意义(P<0.05)。哮喘组CaNO(12.98±7.89)ppb高于非哮喘组(7.89±4.30)ppb,差异有统计学意义(P<0.05)。CaNO与FeNO呈正相关,与第1秒用力呼气容积/用力肺活量(FEV1/FVC)、第1秒用力呼气容积占预计值百分比(FEV1%pred)、25%肺活量时的最大呼气流速占预计值百分比(MEF25%pred)、50%肺活量时的最大呼气流速占预计值百分比(MEF50%pred)、75%肺活量时的最大呼气流速占预计值百分比(MEF75%pred)、用力呼气中期流速占预计值百分比(MMEF%pred)呈负相关。结论哮喘患者FeNO和CaNO越高,提示气道嗜酸性粒细胞炎症越严重,小气道功能越差。
Objective To study the clinical significance of alveolar nitric oxide(CaNO)detection in the patients with asthma.Methods The patients with cough and dyspnea symptoms for more than 3 weeks or asthma history in the outpatients department of this hospital from January 2020 to July 2020 prospectively conducted the oral expiration CaNO and lung function examination,and divided into the asthma group and non-asthma group.The relationship between CaNO and fractional concentration of exhaled nitric oxide(FeNO)with the lung function was compared between the two groups.Results A total of 196 subjects were included,including 88 males(44.9%),108 females(55.1%),115 cases(58.7%)in the asthma group and 81 cases(41.3%)in the non-asthma group.The general data had no statistical difference between the two groups(P>0.05).The mean FeNO value in the asthma group was(45.99±30.63)ppb,which was higher than(18.98±7.91)ppb in the non-asthma group,and the difference was statistically significant(P<0.05).The CaNO value in the asthma group was(12.98±7.89)ppb,which was higher than(7.89±4.30)ppb in the non-asthma group,and the difference was statistically significant(P<0.05).CaNO was positively correlated with FeNO,and negatively correlated with FEV1/FVC,FEV1%pred,MEF25%pred,MEF50%pred,MEF75%pred and MMEF%pred.Conclusion The higher the level of FeNO and Cano in asthmatic patients,indicating that the more severe the eosinophilic inflammation is,the worse the function of small airway is.
作者
陈文丽
韩梅
于超伟
庞桂芬
杨林瀛
赵志伟
姜锋
王少飞
CHEN Wenli;HAN Mei;YU Chaowei;PANG Guifen;YANG Linying;ZHAO Zhiwei;JIANG Feng;WANG Shaofei(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of Chengde Medical College,Chengde,Hebei 067000,China)
出处
《重庆医学》
CAS
2021年第14期2442-2445,共4页
Chongqing medicine
基金
河北省医学科学研究重点课题计划项目(20181157)。
关键词
哮喘
呼出气
一氧化氮
肺功能
相关性
asthma
expired gas
nitric oxide
pulmonary function
relevance
