摘要
目的:探讨妇科盆腔肿瘤术后D-二聚体和纤维蛋白降解产物(FDP)在血凝异常和下肢深静脉血栓(DVT)的诊治意义。方法:回顾性分析芜湖市第一人民医院2016年9月~2020年12月妇科肿瘤手术319例,年龄32~75(41.7±8.5)岁;分为良、恶性肿瘤组,观察术后D-二聚体和FDP值,以及DVT的发生;明确血栓诊断患者给予抗凝治疗。结果:319例妇科盆腔肿瘤术后,发生DVT9例,其中肌间静脉血栓5例、中央型静脉血栓2例、周围型和混合型静脉血栓各1例;妇科肿瘤术后,良性肿瘤组D-二聚体和FDP在正常值范围之内,与良性肿瘤组比较,恶性肿瘤组、DVT组患者术后D-二聚体和FDP升高,差异均有统计学意义(P<0.01);9例患者均无肺栓塞发生。结论:恶性肿瘤和DVT患者D-二聚体和FDP升高;D-二聚体和FDP升高患者应及时行超声或静脉造影检查,早期诊断和治疗是预防肺栓塞发生的关键。
Objective:To investigate the clinical significance of D-dimer and fibrin degradtion products(FDP)in the diagnosis and treatment of abnormal blood coagulation and deep vein thrombosis in women after surgery for pelvic tumor.Methods:Retrospective analysis was performed in 319 cases undergone gynecological surgery for tumor in our hospital between September 2016 and December 2020.The patients′age ranged from 32 to 75 years,with an average(41.7±8.5)years.All cases were divided into benign tumor group and malignant tumor group.The values of D-dimer and FDP as well as incidence of deep vein thrombosis were observed,and patients with definite thrombosis given anticoagulant therapy.Results:Deep vein thrombosis of lower extremity occurred in 9 of the 319 cases following pelvic tumor surgery,including intermuscular vein thrombosis in 5,central vein thrombosis in 2,peripheral vein thrombosis in 1 and mixed vein thrombosis in another one.The values of D-dimer and FDP were within normal range in benign tumor group after pelvic surgery,yet were elevated in malignant tumor group and DVT group.The difference was significant(P<0.01).Pulmonary embolism was free in 9 patients.Conclusion:Significantly elevated D-dimer and FDP level was observed in patients with malignant tumor and deep vein thrombosis.Patients with elevated D-dimer and FDP should undergo timely ultrasound or venous angiography,and early diagnosis and treatment of the thrombosis are critical to prevent incidence of pulmonary embolism.
作者
陈学勤
倪观太
奚旭霞
陈新华
梁双超
CHEN Xueqin;NI Guantai;XI Xuxia;CHEN Xinhua;LIANG Shuangchao(Department of Gynecology&Obstetrics,Wuhu No.1 People′s Hospital,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2021年第4期352-354,共3页
Journal of Wannan Medical College
基金
国家卫计委卫生科技发展项目(W2016CWAH09)
安徽高校自然科学研究重点项目(KJ2018A0267)。
关键词
妇科肿瘤
D-二聚体
纤维蛋白降解产物
下肢深静脉血栓
gynecological neoplasm
D-dimer
fibrin degradtion products
deep vein thrombosis
lower extremity
