摘要
目的:分析孕早期鸢尾素水平与孕妇糖脂代谢及患妊娠期糖尿病风险的相关性。方法:将2018年1月~2019年12月邢台市第三医院行常规产前检查的253例孕妇纳入研究,所有孕妇均于孕早期检测体内血糖、血脂及鸢尾素等实验室指标水平,并根据孕24~28周葡萄糖耐量试验结果将孕妇分为妊娠期糖尿病(GDM)组及无GDM组,比较两组患者的一般资料及相关实验室指标水平,分析孕早期孕妇体内鸢尾素水平与糖脂代谢的相关性。结果:GDM组孕妇的BMI,孕早期空腹血糖(FPG)、餐后2 h血糖(2 h PBG)、糖化血红蛋白(HbA1c)及甘油三脂(TG)水平高于无GDM组,HDL-C及鸢尾素水平低于无GDM组(均P<0.05);多因素Logistics分析显示高BMI,孕早期高FPG、PBG、HbA1c及TG水平是妊娠期糖尿病的独立危险因素(均P<0.05),而高鸢尾素水平是妊娠期糖尿病的保护因素(P<0.05);且孕早期孕妇体内鸢尾素水平与HbA1c呈负相关,与HDL-C呈正相关(均P<0.05)。结论:孕早期孕妇体内低鸢尾素水平是发生妊娠期糖尿病的独立危险因素,与孕妇的糖脂代谢指标密切相关。
Objective:To analyze the risks of gestational diabetes between irisin level in the first trimester and glucose and lipid metabolism.Methods:253 pregnant women undergoing routine prenatal check-ups in our hospital were included from January 2018 to December 2019.All of them received test of blood glucose,blood lipids and irisin as well as other laboratory studies in the first trimester.The women were then divided into GDM group and non-GDM group by the results of glucose tolerance tested at 24-28 weeks of gestation.The general data and relevant laboratory index levels were compared between the two groups,and the correlation was analyzed between the level of irisin and glucose and lipid metabolism in early pregnancy.Results:The BMI,FPG,2 h PBG,HbA1c and TG levels were significantly higher,yet HDL-C and irisin levels were lower in GDM group than in non-GDM group(all P<0.05).Multivariate logistic analysis showed that high level of BMI,FPG,PBG,HbA1c and TG in the first trimester was independent risk factors for gestational diabetes(all P<0.05),whereas high irisin level was protective role for gestational diabetes(P<0.05),and the levels of iris and HbA1c in early pregnancy were negatively correlated with HbA1c,yet positively with HDL-C(all P<0.05).Conclusion:Low level of iris in the first trimester is an independent risk factor for gestational diabetes,and closely related to glucose and lipid metabolism in pregnant women.
作者
吴棣
刘子宸
高妍
王文丽
WU Di;LIU Zichen;GAO Yan;WANG Wenli(Department of Obstetrics,The Third Hospital of Xingtai City,Xingtai 054000,China)
出处
《皖南医学院学报》
CAS
2021年第4期369-371,共3页
Journal of Wannan Medical College
基金
邢台市科技计划项目(2017ZC083)。
关键词
鸢尾素
糖脂代谢
妊娠期糖尿病
irisin
glucose and lipid metabolism
gestational diabetes
