摘要
Embryonic stem cells(ESCs)provide an ideal model for investigating developmental processes and are great sources for developing regenerative m edicine.Harnessing apoptosis facilitates accurate recapitulation of signalling events during em bryogenesis and allows efficient expansion of the ESCs during differentiation.Bcl2,a key regulator of intrinsic anti-apoptotic pathway,encodes two splicing isoforms.However,the identification and functional comparison of Bcl2 splicing isoforms in mouse ESCs(mESCs)remains to be elucidated.Here,we provide the evidence that both Bcl2 splicing variants are expressed in mESCs.Despite the structural difference,they have similar subcellular localization.
出处
《解剖学杂志》
CAS
2021年第S01期219-220,共2页
Chinese Journal of Anatomy
