摘要
为了解决聚氯乙烯(PVC)医用耗材在使用过程中易被细菌感染问题,采用一步法合成了一种新型抗菌剂——C8-6-8双季铵盐(GQAS),并将其作为添加剂与PVC粒料进行物理共混和压片,制成了一种抗菌性能良好的改性PVC材料。采用核磁共振波谱仪(1H-NMR)、热重分析仪(TG)、菌落计数仪和电子万能材料试验机对GQAS的结构和热稳定性以及改性PVC材料的抗菌性能、溶出能力和力学性能进行了表征。结果表明,GQAS与PVC共混时不会因加热而分解;GQAS含量为5%(质量分数,下同)的改性PVC材料可以有效抑制大肠杆菌和金黄色葡萄球菌的生长;在被浸泡7 d后,GQAS含量为5%的改性PVC材料仍具有不错的抗菌能力;2%或5%GQAS改性PVC材料的拉伸强度(23.3或18.9 MPa)和断裂伸长率(318.8%或295.3%)与纯PVA(24.6 MPa,341.5%)相比均有所下降,但总体仍在可接受范围。
To solve the problem that poly(vinyl chloride)(PVC)medical consumables are easily infected by bacteria during the use,a new type of antibacterial agent,C8-6-8 gimini quaternary ammonium salt(GQAS),was synthesized. This new quaternary ammonium salt was then used as an additive to blend with PVC physically. The resultant blends were compressed to pellets as a type of modified PVC materials with good antibacterial properties. The structure and thermal stability of GQAS and the antibacterial properties,dissolution capacity and mechanical properties of modified PVC materials were characterized using nuclear magnetic resonance spectrometer,thermogravimetric analyzer,colony counter,and electronic universal material testing machine. The results indicated that GQAS did not decompose with heating when blended with PVC. The modified PVC material containing 5 wt% GQAS can effectively inhibit the growth of E. coli and S. aureus. After soaked for 7 days,the modified PVC materials containing 5 wt% GQAS still had a good antibacterial capability. The modified PVC materials showed a decrease in tensile strength(22. 3 or 18. 9 MPa)and elongation at break(318. 8 % or 295. 3 %)comparing with pure PVC(24. 6 MPa,341. 5 %),which was still in an acceptable range.
作者
张耀成
吴勇振
李阳
赵竹
王国胜
丁雪佳
ZHANG Yaocheng;WU Yongzhen;LI Yang;ZHAO Zhu;WANG Guosheng;DING Xuejia(Beijing Laboratory of Biomedical Materials,Beijing University of Chemical Technology,Beijing 100048,China;Henan Tuoren Medical Equipment Group Co,Ltd,Xinxiang 453000,China)
出处
《中国塑料》
CAS
CSCD
北大核心
2021年第7期53-57,共5页
China Plastics
基金
国家重点研发计划植/介入医用导管及器械表面超亲水超润滑改性研究(2020YFC1107300)
国家重点研发计划隐形矫治器材料(2017YFC1104304)。
关键词
双季铵盐
聚氯乙烯
抗菌
共混
溶出
gimini quaternary ammonium salt
poly(vinyl chloride)
antibacterial
blending
migration
