摘要
牙周病是一种以牙周袋形成、牙槽骨吸收为主要临床特征的口腔慢性感染性疾病。牙周病患者受损牙周组织的再生一直是学者们研究的热点。研究发现,锶在促进牙周组织再生方面具有一定的潜力。近年来,不断有学者就锶与牙周组织再生进行研究,以期为牙周病治疗提供新的思路。本文将对锶与牙周组织再生的研究现状进行综述。综述结果表明,锶可以诱导牙周膜间充质干细胞(periodontal ligament stem cells,PDLSCs)增殖及成骨分化,促进丢失骨组织重新生成;可以通过多种信号通路抑制破骨细胞活性、诱导破骨细胞凋亡,从而抑制骨吸收;促进成骨细胞增殖分化,促进骨形成。此外,锶还具有促进早期血管生成和抑制免疫炎症反应的功能。目前,锶与牙周组织再生的研究仅仅集中在体内外实验,还没有相关临床试验将锶应用于牙周组织再生中,因此,想通过锶促进牙周组织再生达到牙周病的治疗仍需进一步研究。
Periodontal disease is a chronic infectious disease of the oral cavity. Its main clinical features are periodontal pocket formation and alveolar bone resorption. Scholars’ research hotspot is to achieve periodontal tissue regeneration in patients.Studies have found that strontium has a certain potential in promoting periodontal tissue regeneration. In recent years,scholars have been conducting researches on strontium and periodontal tissue regeneration,with a view to opening a new path for periodontal disease treatment. This article reviews the research status of strontium and periodontal tissue regeneration. The review results show that strontium can induce the proliferation and differentiation of periodontal ligament stem cells(PDLSCs)and promote the regeneration of lost bone tissue,and also it can inhibit osteoclast activity and induce osteoclast apoptosis through a variety of signaling pathways,thereby inhibiting bone resorption. In addition,strontium promotes bone formation and has the function of promoting early angiogenesis and suppressing immune inflammatory response. Because the current research on strontium and periodontal tissue regeneration is only focused on in vivo and in vitro experiments,there is no relevant clinical trial to apply strontium to periodontal tissue regeneration. Therefore,if strontium is used to promote periodontal tissue regeneration to achieve the treatment of periodontal disease,further research is needed.
作者
任百洁
邹馨颖
刘悦
王雷
高东辉
RENBai-jie;ZOUXin-ying;LIUYue;WANGLei;GAODong-hui(DepartmentofEndodontics,SchoolandHospitalofPeriodontology,JilinUniversity,Changchun 130021,China)
出处
《海南医学院学报》
CAS
2021年第15期1192-1196,共5页
Journal of Hainan Medical University
基金
吉林省科技发展计划项目(20190303183SF)
吉林大学本科教学改革研究项目(2019XYB318)
吉林省自然科学基金(学科布局项目20200201389JC)。
