摘要
From a further purification study,two new congeners designated cyslabdans B(1)and C(2)were isolated along with previously reported cyslabdan(cyslabdan A(3)in this study)from the culture broth of Streptomyces sp.K04-0144.The structure was elucidated by various spectroscopy including NMR,revealing that 1 and 2 was 18-hydroxy and 10-methoxy cyslabdan,respectively.Compounds 1 and 2 were found to potentiate imipenem activity against methicillinresistant Staphylococcus aureus by 123 fold and 533 fold,respectively.Comparison with the activity of compound 3 indicated that the introduction of a hydrophilic group at the dimethyl moiety of the decalin ring was unfavorable for its activity.
基金
supported in part by Grants from Kakenhis 21310146(to H.T.)
23790020(to N.K.)from the Ministry of Education,Culture,Sports,Science,and Technology of Japan
the Uehara Memorial Foundation(to H.T.)
a Kitasato University Research Grant for Young Researchers(to N.K.).
