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Therapeutic strategies for a functional cure of chronic hepatitis B virus infection 被引量:5

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摘要 Treatment of chronic hepatitis B virus(HBV)infection with the viral DNA polymerase inhibitors or pegylated alpha-interferon has led to a significant retardation in HBV-related disease progression and reduction in mortality related to chronic hepatitis B associated liver decompensation and hepatocellular carcinoma.However,chronic HBV infection remains not cured.The reasons for the failure to eradicate HBV infection by long-term antiviral therapy are not completely understood.However,clinical studies suggest that the intrinsic stability of the nuclear form of viral genome,the covalently closed circular(ccc)DNA,sustained low level viral replication under antiviral therapy and homeostatic proliferation of hepatocytes are the critical virological and pathophysiological factors that affect the persistence and therapeutic outcomes of HBV infection.More importantly,despite potent suppression of HBV replication in livers of the treated patients,the dysfunction of HBV-specific antiviral immunity persists.The inability of the immune system to recognize cells harboring HBV infection and to cure or eliminate cells actively producing virus is the biggest challenge to finding a cure.Unraveling the complex virus–host interactions that lead to persistent infection should facilitate the rational design of antivirals and immunotherapeutics to cure chronic HBV infection.
出处 《Acta Pharmaceutica Sinica B》 SCIE CAS 2014年第4期248-257,共10页 药学学报(英文版)
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  • 1Fu-Sheng Wang Li-He Xing Ming-Xu Liu Chuan-Lin Zhu Hui-Gang Liu Hui-Fen Wang Zhou-Yun Lei Division of Biological Engineering,~2 Fourth Department of Liver Diseases,Beijing Institute of Infectious Diseases,Beijing Hospital of Infectious Diseases,Beijing 100039,China.Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection[J].World Journal of Gastroenterology,2001,7(4):537-541. 被引量:131
  • 2MinChen,Yong-GuoLi,Da-ZhiZhang,Zhi-YiWang,Wei-QunZeng,Xiao-FengShi,YuanGuo,Shu-HuaGuo,HongRen.Therapeutic effect of autologous dendritic cell vaccine on patients with chronic hepatitis B: A clinical study[J].World Journal of Gastroenterology,2005,11(12):1806-1808. 被引量:40
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