摘要
目的分析荧光素纳眼底血管造影术(FFA)和吲哚菁绿眼底血管造影术(ICGA)的不良反应与患者年龄、性别、疾病种类的关系。方法选取2000年1月—2019年1月于温州医科大学附属眼视光医院就诊,过敏试验结果阴性并行FFA和ICGA检查的31475例患者。记录患者不良反应发生时间、检查项目、性别、年龄、眼部疾病种类、是否出现不良反应及不良反应的严重程度。结果共4679例患者出现不良反应,轻度4367例(13.87%),中度277例(0.90%),重度22例(0.07%)。95.72%不良反应发生在用药后5 min内。行FFA检查患者4125例出现不良反应,轻度3813例、中度277例、重度22例、未记录严重程度13例。FAA检查有无出现不良反应患者的年龄、性别和疾病构成比较,差异有统计学意义(P<0.05)。行ICGA检查患者73例出现不良反应,均为轻度,ICGA有无出现不良反应患者的年龄比较,差异有统计学意义(P<0.05),性别构成比较,差异无统计学意义(P>0.05)。同时行FFA和ICGA患者481例出现不良反应,均为轻度,联合检查有无出现不良反应患者的年龄比较,差异有统计学意义(P<0.05),性别构成比较,差异无统计学意义(P>0.05)。结论过敏试验无法完全预测是否会发生不良反应。年轻患者更容易出现FFA和ICGA的不良反应,不同疾病出现不良反应概率不同,需要更加重视年轻患者和更易出现不良反应的疾病在造影开始后1 h内的检查,确保临床用药安全。
Objective To analyze the relationship of the adverse reactions of fundus fluorescein angiography(FFA)and indocyanine angiography(ICGA)with the patients'age,gender and disease types.Methods We selected 31,475 patients with anaphylaxis test being negative and undergoing FFA and/or ICGA in our hospital from January 2000 to January 2019 as the study subjects,and the incidence,time to onset and severity of adverse reactions,examination items,gender,age,and types of eye diseases were recorded.Results A total of 4,679 patients developed adverse reactions,with 4,367 mild cases(13.87%),277 moderate cases(0.90%)and 22 severe cases(0.07%),and 95.72%of the adverse reactions occurred within 5 minutes.Specifically,4,125 patients undergoing FFA alone had adverse reactions,with 3,813 mild cases(15.34%),277 moderate cases(1.11%),22 severe cases(0.09%)and 13 undetermined cases.There were differences in the age,gender and disease composition between patients with and without adverse reactions after FFA alone(P<0.05).In contrast,872 patients were examined by ICGA alone,and only 73 patients(8.4%)had mild adverse reactions,with differences in the age and disease composition(P<0.05)but no difference in gender composition between patients with and without adverse reactions(P>0.05).There were still 5,749 cases examined by both FFA and ICGA,and 481 of them(8.4%)had mild adverse reactions.The age and disease composition(P<0.05)rather than the gender composition(P>0.05)were different between patients with and without adverse reactions in these cases.Conclusions Anaphylaxis test can not completely predict the occurrence of adverse reactions.Young patients are more likely to develop adverse reactions after FFA and ICGA,and different diseases contribute to different risks of adverse reactions.We need to pay more attention to young patients and diseases that are more susceptible to adverse reactions within 1 h after angiography to ensure safety.
作者
沈小秋
黄颖
郑燕
周容
周挺业
林冰
Xiao-qiu Shen;Ying Huang;Yan Zheng;Rong Zhou;Ting-ye Zhou;Bing Lin(Department of Fundus Medicine,Eye Hospital Affiliated to Wenzhou Medical University,Wenzhou,Zhejiang 325027,China)
出处
《中国现代医学杂志》
CAS
北大核心
2021年第14期85-91,共7页
China Journal of Modern Medicine
