摘要
目的探讨银杏内酯联合丁苯酞对大动脉粥样硬化性缺血性脑卒中患者的疗效及神经功能的影响。方法选取我院2017年3月至2019年6月期间接诊的200例大动脉粥样硬化性缺血性脑卒中患者作为研究对象。按照随机数字表法将其随机分为研究组和对照组,每组各100例。对照组采用丁苯酞治疗,研究组在对照组基础上联合银杏内酯进行治疗。在治疗前和治疗后15 d分别记录两组患者超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、红细胞压积(HCT)、总胆固醇水平(TC)、大动脉粥样硬化患者近期、远期结局及神经功能缺损评分。结果研究组患者用药80 d后的卒中量表(NIHSS)评分、Rankin量表(mRS)评分较对照组明显降低(P<0.05),研究组患者Barthel量表(BI)指数较对照组明显升高(P<0.05);治疗前,两组患者hs-CRP、IL-6、HCT、TC浓度比较,差异无统计学意义(P>0.05);治疗后,研究组hs-CRP、IL-6、HCT、TC浓度明显低于对照组(P<0.05)。治疗后,两组患者血清中BDNF水平均显著提高,与治疗前比较,NSE、GFAP水平明显降低(P<0.05),治疗后,研究组BDNF水平研究组明显高于对照组,研究组NSE、GFAP水平明显低于对照组(P<0.05)。不良反应发生率明显低于对照组(P<0.05)。结论银杏内酯联合丁苯酞治疗大动脉粥样硬化性缺血性脑卒中可有效改善炎性细胞因子,促进神经功能恢复,减少神经功能损伤,且其安全性较高,具有临床应用价值,值得推广。
Objective To explore the impacts of ginkgolides combined with butylphthalide on the therapeutic efficacy and neurological function in patients with large artery atherosclerotic ischemic stroke.Methods A total of 200 patients with large artery atherosclerotic ischemic stroke diagnosed in our hospital from March 2017 to June 2019 were selected as the research objects.They were divided into the study group(n=100)and the control group(n=100)according to the random number table method.The control group was treated with butylphthalide,while the study group was treated with ginkgolides on the basis of the control group.The levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),hematocrit(HCT),total cholesterol level(TC),short-term and long-term outcomes of patients with large artery atherosclerosis and neurological function deficit scores of two groups of patients before and 15 days after treatment were recorded,respectively.Results After 80 days of medication,the scores of stroke scale(National Institutes of Health Stroke Scale,NIHSS)and modified Rankin scale(mRS)in patients of the study group were significantly lower than those of the control group(P<0.05).The Barthel index(BI)in patients of the study group was significantly higher than those of the control group(P<0.05).Before treatment,the levels of hs-CRP,IL-6,HCT and TC were compared between the two groups of patients(P>0.05).After treatment,the levels of hs-CRP,IL-6,HCT and TC in the study group were signifi cantly lower than those in the control group(P<0.05).After treatment,the levels of brain derived neurotrophic factor(BDNF)in serum of both groups were significantly increased,while the levels of neuron specific enolase(NSE)and glial fibrillary acidic protein(GFAP)were significantly lower than those before treatment(P<0.05).After treatment,BDNF levels in the study group were significantly higher than those in the control group,while NSE and GFAP levels in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusion Ginkgolides combined with butylphthalide can effectively improve inflammatory cytokines in patients with large artery atherosclerotic ischemic stroke,promote the recovery of neurological function,reduce the damage of neurological function,and is relatively safe.Therefore,it is worthy of application and promotion in clinic.
作者
梁燕飞
朱英标
LIANG Yanfei;ZHU Yingbiao(Department of Neurosurgery,Lishui City People′s Hospital in Zhejiang Province,Lishui 323000,China)
出处
《中国现代医生》
2021年第18期11-14,18,共5页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2021KY1233)。
关键词
银杏内酯
丁苯酞
大动脉粥样硬化性缺血性脑卒中
神经功能
疗效
Ginkgolide
Butylphthalide
Large artery atherosclerotic ischemic stroke
Neurological function
Therapeutic efficacy
