摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)与卵圆孔未闭患者卒中发生风险的相关性。方法回顾性连续纳入2018年3月至2020年3月郑州大学第五附属医院诊断为卵圆孔未闭的患者102例,其中有40例(39.22%)有中风,而62例(60.78%)没有中风。入院24 h内完善相关检查,包括血常规和血生化、凝血、头颅影像学、经颅多普勒超声发泡试验(c TCD)及右心声学造影等,并计算NLR值。根据cTCD结果将卵圆孔未闭患者分为:小量分流组、中量分流组、大量分流组,对比不同组间发生卒中的风险及卒中后神经功能缺损的严重程度。结果 NLR越高发生卒中风险越大(2.98±1.46 vs. 1.96±1.17,P=0.03)。未闭卵圆孔分流越多,发生卒中风险越高(χ^(2)=7.34,P=0.025),发生卒中后神经功能缺损症状越重(χ^(2)=6.20,P=0.045)。结论卵圆孔未闭患者中性粒细胞与淋巴细胞的比率升高可能与隐源性卒中有关,卵圆孔分流越多,卒中后神经功能缺损症状越重。
Objective To investigate the correlation between neutrophil to lymphocyte ratio(NLR)and stroke risk in patients with patent foramen ovale.Methods A total of 102 patients diagnosed as patent foramen ovale in the Fifth Af-filiated Hospital of Zhengzhou University from March 2018 to March 2020 were included retrospectively and consecu-tively.And there were 40 patients(39.22%)with stroke,while 62 patients(60.78%)without stroke.Within 24 hours af-ter admission,related examinations were completed,including blood routine and blood biochemistry,coagulation,cra-nial imaging,transcranial Doppler bubble test(cTCD)and right heart contrast echocardiography,and the NLR value was calculated.According to the results of cTCD,the patients with patent foramen ovale were divided into the small volume shunt group,the medium volume shunt group and the large volume shunt group.The risk of stroke and the severity of neurological deficit after stroke were compared in different groups.Results The higher the NLR,the greater the risk of stroke(2.98±1.46 vs 1.96±1.17,P=0.03).The more volume shunt of patent foramen ovale,the higher the risk of stroke(χ^(2)=7.34,P=0.025),and the more severe the symptoms of neurological deficit after stroke(χ^(2)=6.20,P=0.045).Conclusion This research suggests that the increase of NLR in patients with patent foramen ovale may be related to cryptogenic stroke.The more volume shunt of foramen ovale,the more severe the symptoms of neurological deficit after stroke.
作者
潘双杰
何远宏
赵源征
朱迎慧
晁志文
PAN Shuangjie;HE Yuanhong;ZHAO Yuanzheng;ZHU Yinghui;CHAO Zhiwen(Department of Neurology,The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国现代医生》
2021年第18期91-94,共4页
China Modern Doctor
