摘要
目的探讨生长激素缺乏症(GHD)儿童骨代谢标志物水平,评估骨代谢标志物作为GHD儿童骨骼生长发育监测指标的作用。方法选择134例GHD确诊儿童纳入GHD组,其中男83例,女51例。选择同期134例健康儿童纳入对照组,其中男83例,女51例。分别检测各组骨代谢标志物1型前胶原氨基末端肽(P1NP)、N-端骨钙素(N-MID)、1型胶原β-C末端肽(β-CTX)水平,以及胰岛素样生长因子-1(IGF-1)、空腹胰岛素(INS0)、维生素D(VD)、空腹血糖(FPG)、胰岛素样生长因子结合蛋白3(IGF1-3bp)水平。结果GHD组男童和女童IGF-1、INS0、VD水平与对照组比较,差异有统计学意义(P<0.05),GHD组女童>8~12岁年龄段、GHD组男童各年龄段的IGF1-3bp水平与同年龄段、同性别的对照组比较,差异有统计学意义(P<0.05)。GHD组和对照组女童β-CTX各个年龄段水平差异均有统计学意义(P<0.05),GHD组和对照组男童P1NP、β-CTX和N-MID各个年龄段水平差异均有统计学意义(P<0.05)。结论骨代谢标志物能够很好地反映GHD儿童体内骨代谢、转换的动态情况,可以作为儿童生长激素缺乏的早期评估、预后判断指标。
Objective To investigate the levels of bone metabolism markers in children with growth hormone deficiency(GHD),to evaluate their role as the monitor indicators of bone growth and development in GHD children.Methods A total of 134 children cases diagnosed GHD were selected as the GHD group,including 83 males and 51 females.A total of 134 healthy children were selected as the control group during the same period,including 83 males and 51 females.The levels of bone metabolism markers type 1 procollagen amino-terminal peptide(P1NP),N-terminal midfragment of osteocalcin(N-MID),β-C-terminal telopeptide of type 1 collagen(β-CTX)as well as the levels of insulin-tike growth factor 1(IGF-1),fasting insulin(INS0),Vitamin D(VD),fasting blood glucose(FPG)and insulin-like growth factor binding protein-3(IGF1-3bp)in each group were tested respectively.Results The levels of IGF-1,INS0 and VD in the boys and girls had statistical differences between the GHD group and control group(P<0.05).The level of IGF1-3bp in girls aged>8-12 years old of the GHD group and different ages of boys in the GHD group had statistical differences compared with the same age and same sex of the control group(P<0.05).Theβ-CTX level had statistical difference among different age groups of girls in the GHD group and control group(P<0.05),while the levels of P1NP,β-CTX and N-MID had statistical difference among different age groups of boys in the GHD group and control group at all ages(P<0.05).Conclusion The bone metabolism markers can well reflect the dynamic situation of bone metabolism and transformation in children with GHD,which can serve as the indicators for early assessment and prognosis judgment of children with GHD.
作者
王永梅
江咏梅
于凡
周文杰
张益多
张静
WANG Yongmei;JIANG Yongmei;YU Fan;ZHOU Wenjie;ZHANG Yiduo;ZHANG Jing(Department of Clinical Laboratory,West China Second Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education,West China Second Hospital,Sichuan University,Chengdu,Sichuan 610041,China)
出处
《国际检验医学杂志》
CAS
2021年第15期1807-1810,共4页
International Journal of Laboratory Medicine
基金
四川省科技计划项目(2020YFS0107)。
关键词
生长激素缺乏症
骨代谢标志物
生长发育
儿童
growth hormone deficiency
bone metabolism marker
growth and development
children
