摘要
目的探讨血清脂联素(APN)、D-二聚体(D-D)水平对ST段抬高型心肌梗死(STEMI)患者介入治疗预后的影响。方法选取2018年11月至2020年11月商丘市中医院收治的100例STEMI患者为研究对象。均行介入治疗,随访1个月后,评估短期预后情况;并检测患者介入治疗前血清APN、D-D水平,分析血清APN、D-D水平对STEMI患者介入治疗预后的影响。结果随访1个月,100例STEMI患者介入治疗后,65例预后良好,占65.00%(65/100),35例患者预后不良,占35.00%(35/100);预后不良组血清APN水平低于预后良好组,D-D水平高于预后良好组,差异有统计学意义(P<0.05);组间其他基线资料比较,差异无统计学意义(P>0.05);经logistic回归分析结果显示,血清APN水平低表达,D-D水平高表达可增加STEMI患者介入治疗预后不良的风险(OR>1,P<0.05);绘制受试者工作(ROC)曲线显示:血清APN、D-D水平单项及联合预测STEMI患者介入治疗预后不良的曲线下面积(AUC)分别为0.835、0.854、0.868(>0.7),具有一定的预测价值,且联合诊断的价值更高。结论血清APN、D-D水平可影响STEMI患者介入治疗预后情况,血清APN水平低表达,D-D水平高表达,可能提示患者预后越差,通过检测血清APN、D-D水平可预测STEMI患者介入治疗预后情况,且两指标联合检测的预测价值更高。
Objective To investigate the effect of serum adiponectin(APN)and D-Dimer(D-D)levels on the prognosis of patients with ST elevation myocardial infarction(STEMI)after interventional therapy.Methods One hundred STEMI patients treated in Shangqiu Hospital of Traditional Chinese Medicine from November 2018 to November 2020 were selected as the research subjects.All patients were treated with interventional therapy.The short-term prognosis was evaluated after one month of follow-up.The levels of serum APN and D-D of patients were measured before intervention.The influence of serum APN and D-D levels on the prognosis of STEMI patients after interventional therapy was analyzed.Results After one month of follow-up,among 100 STEMI patients after interventional therapy,65 patients had a good prognosis,accounting for 65.00%(65/100),and 35 patients had poor prognosis,accounting for 35.00%(35/100).The level of serum APN in the poor prognosis group was lower than that in the good group,and the D-D level was higher than that of the good group.The differences were statistically significant(P<0.05).There was no statistical statistical difference in other baseline data between the two groups(P>0.05).The results of logistic regression analysis showed that the low expression of serum APN level and high expression of D-D level could increase the risk of poor prognosis in STEMI patients(OR>1,P<0.05).The receiver operating curve(ROC)was drawn and showed that the area under the curve(AUC)of serum APN and D-D levels alone and in combination in predicting poor prognosis of STEMI patients after interventional therapy were 0.835,0.854 and 0.868(>0.7),respectively.All had certain predictive value,and the value of combined diagnosis was higher.Conclusion The levels of serum APN and D-D can affect the prognosis of patients with STEMI after interventional therapy.The low expression of serum APN level and high expression of D-D level may indicate the worse prognosis of patients.The detection of serum APN and D-D levels can predict the prognosis of STEMI patients after interventional therapy,and the combined detection of the two indexes has higher predictive value.
作者
陈贺
CHEN He(Department of Clinical Laboratory,Shangqiu Hospital of Traditional Chinese Medicine,Shangqiu 476000,China)
出处
《河南医学研究》
CAS
2021年第18期3423-3426,共4页
Henan Medical Research
关键词
ST段抬高型心肌梗死
脂联素
D-二聚体
介入治疗
相关性
ST segment elevation myocardial infarction
adiponectin
D-dimer
interventional therapy
relevance
