摘要
Localization optoacoustic tomography provides superresolution imaging capability in 3D beyond the acoustic diffraction limit,which can be crucial for mapping microcirculation in cancers,brain functions,peripheral vascular diseases,etc.Optoacoustic(also referred to as photoacoustic)tomography(OAT)has been gaining popularity for preclinical and clinical imaging during the past couple of decades1.OAT breaks the long-standing shallow imaging depth limitation of conventional optical imaging by forming an image using the optoacoustic(OA)effect.Through advances in ultrasound imaging technologies,OAT provides rich optical contrast while achieving high spatial resolution deep inside living subjects(up to several centimeters).Thanks to these hybrid technologies,the use of preclinical OAT to study cancer physiopathology,neural physiology,drug delivery,vascular diseases,etc.,has spread globally to many laboratories.More importantly,the applications of OAT have been extended to include many clinical trials,such as early diagnosis and treatment monitoring of cancers,imaging of the bowel for diseases,human neuroimaging for diagnosing neurological defects,imaging of peripheral arteries and veins for detecting vascular disease,and intravascular imaging for characterizing plaque.
基金
supported by the MSIT(Ministry of Science and ICT)
Korea,under the ICT Consilience Creative program(IITP-2018-2011-1-00783)
supervised by the IITP(Institute for Information&communications Technology Promotion)
the grant of the Korea Health Technology R&D Project(HI15C1817)through the KHIDI(Korea Health Industry Development Institute)
funded by the Ministry of Health&Welfare,Republic of Korea,the NRF(National Research Foundation)grant(2011-0030075)funded by MSIT,Republic of Korea.
