摘要
目的:探讨急性心肌梗死(AMI)患者应用rh-BNP治疗的效果及对患者预后与心功能的影响。方法:选取2019年5月-2020年5月本院收治的AMI患者108例。随机分为对照组和研究组,每组54例。对照组应用常规治疗,研究组在对照组基础上应用重组人脑利钠肽(rh-BNP)治疗。比较两组的治疗效果、LVEDV、LVESV、LVEF、NT-proBNP、hs-CRP和心血管事件的发生情况。结果:研究组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,研究组LVEDV、LVESV、LVEF水平均优于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组NT-proBNP、hs-CRP水平均低于对照组,差异均有统计学意义(P<0.05)。研究组心血管事件发生率低于对照组,差异有统计学意义(P<0.05)。结论:AMI患者应用rh-BNP治疗,可增强治疗效果,有效抑制炎症反应,减轻心室负荷。同时还可恢复AMI患者的心功能,改善心肌灌注,降低不良事件的发生情况,从而有利于提高远期预后情况,在临床上值得进一步应用推广。
Objective:To investigate the effect of rh-BNP in patients with acute myocardial infarction and the influence on prognosis and cardiac function.Method:A total of 108 AMI patients admitted to our hospital from May 2019 to May 2020 were selected.They were randomly divided into control group and study group,54 cases in each group.The control group was treated with conventional treatment,and the study group was treated with recombinant human brain natriuretic peptide(rh-BNP).The treatment effect,LVEDV,LVESV,LVEF,NT-proBNP,hs-CRP and the occurrence of cardiovascular events were compared between the two groups.Result:The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of LVEDV,LVESV and LVEF in the study group were better than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of NT-proBNP and hs-CRP in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of cardiovascular events in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The application of rh-BNP in patients with AMI can enhance the therapeutic effect,effectively inhibit the inflammatory response,and reduce the ventricular load.At the same time,it can also restore the cardiac function of AMI patients,improve myocardial perfusion,reduce the occurrence of adverse events,so as to improve the long-term prognosis,which is worthy of further application and promotion in clinical practice.
作者
刘鸿玲
殷实
LIU Hongling;YIN Shi(Jiamusi Central Hospital,Jiamusi 154002,China;不详)
出处
《中国医学创新》
CAS
2021年第17期18-22,共5页
Medical Innovation of China
关键词
急性心肌梗死
rh-BNP
预后
心功能
Acute myocardial infarction
rh-BNP
Prognosis
Cardiac function
