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RMI2 plays crucial roles in growth and metastasis of lung cancer 被引量:1

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摘要 Dear Editor,Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death in the world,but its therapeutic targets are still being explored.Genome instability as a key hallmark of cancer not only contributes to cancer initiation and progression,1 but also creates vulnerabilities that are relatively specific to cancer cells,which may be potential therapeutic targets for cancer patients.During DNA Double-Strand Breaks(DSBs)repair,BTR(BLM-Topo IIIα-RMI1/RMI2)complex promotes the dissolution of double Holliday junctions to form non-crossover products and is often considered as a tumor suppressor.2 However,the function of each individual component of this BTR complex in cancer remains largely unknown.
出处 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2020年第1期907-909,共3页 信号转导与靶向治疗(英文)
基金 supported by the National Key Research and Development Program of China(2016YFA0500304 to T.K.) the Fundamental Research Funds for the Central Universities(17ykjc27 to T.K.) the National Nature Science Foundation in China(NSFC)(81530081 to T.K.,81772922 to Y.W.).
关键词 CANCER METASTASIS LUNG
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