摘要
目的:探讨胰岛素联合阿司匹林治疗妊娠期糖尿病孕妇的效果及其对血糖水平的影响。方法:选取2019年4月-2020年4月本院收治的134例妊娠期糖尿病患者,应用随机数字表法分为对照组和研究组,每组67例。对照组采用单纯胰岛素治疗,研究组采用胰岛素联合阿司匹林治疗。比较两组妊娠情况和新生儿结局及治疗前后的血糖指标[糖化血红蛋白(HbA1c)、空腹血糖(FBG)及餐后2h血糖(2h PBG)]、镁离子(Mg^(2+))、内脂素(VF)、血脂指标[甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]、血浆黏度和血小板聚集率。结果:研究组妊娠情况及新生儿结局均优于对照组,差异均有统计学意义(P<0.05)。治疗前,两组FBG、2h PBG、HbA1c比较,差异均无统计学意义(P>0.05),治疗后,研究组FBG、2h PBG、HbA1c均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组Mg^(2+)、VF比较,差异均无统计学意义(P>0.05);治疗后,研究组Mg^(2+)高于对照组,VF低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组TG、TC、LDL-C、HDL-C比较,差异均无统计学意义(P>0.05);治疗后,两组TG、TC及LDL-C均低于治疗前,HDL-C均高于治疗前,差异均有统计学意义(P<0.05)。研究组TG、TC及LDL-C均低于对照组,HDL-C高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组血浆黏度、血小板聚集率比较,差异均无统计学意义(P>0.05);治疗后,研究组血浆黏度及血小板聚集率均低于对照组,差异均有统计学意义(P<0.05)。结论:胰岛素与阿司匹林联合治疗妊娠期糖尿病产妇效果较好,可以改善控制血糖及血脂水平,有利于改善妊娠情况及新生儿结局,值得临床推广。
Objective:To investigate the effect of Insulin combined with Aspirin in the treatment of pregnant women with gestational diabetes mellitus and its effect on blood glucose level.Method:A total of 134 patients with gestational diabetes mellitus in our hospital from April 2019 to April 2020 were selected,and they were divided into control group and study group according to random number table method.The control group was treated with Insulin alone,and the study group was treated with Insulin combined with Aspirin.The pregancy situation,neonatal outcomes were compared between two groups,and blood glucose indexes[HbA1c,fasting blood glucose(FBG)and 2 h postprandial blood glucose(2 h PBG)],magnesium(Mg^(2+)),visfatin(VF),blood lipid indicators[TG,cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)],plasma viscosity and platelet aggregation rate before and after treatment were compared between two groups.Result:The pregnancy situation and neonatal outcomes of study group were superior than those of control group,the difference were statistically significant(P<0.05).Before treatment,there were no significant differences in FBG,2 h PBG and HbA1c between two groups(P>0.05);after treatment,FBG,2 h PBG and HbA1c of study group were lower than those of control group,the difference were statistically significant(P<0.05).Before treatment,there was no significant differences in levels of Mg^(2+) and VF between two groups(P>0.05);after treatment,Mg^(2+) of study group was higher than that of control group,while VF of study group was lower than that of control group,the difference were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in TG,TC,LDL-C and HDL-C between two groups(P>0.05);after treatment,TG,TC and LDL-C of both groups were lower than before treatment,while HDL-C were higher than before treatment,the difference were statistically significant(P<0.05).TG,TC and LDL-C of study group were lower than those of control group,while HDL-C was higher than that of control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in plasma viscosity and platelet aggregation rate between two groups(P>0.05);after treatment,the plasma viscosity and platelet aggregation rate of study group were lower than those of control group,the differences were statistically significant(P<0.05).Conclusion:Insulin combined with Aspirin in the treatment of pregnant women with gestational diabetes mellitus has a significant effect,can significantly control blood glucose and blood lipid levels,is conducive to improve the pregnancy and neonatal outcomes,worthy of clinical promotion.
作者
杨宏
YANG Hong(Jiamusi Maternal and Child Health Hospital,Jiamusi 154000,China)
出处
《中国医学创新》
CAS
2021年第19期35-39,共5页
Medical Innovation of China
