摘要
目的:探讨百令胶囊联合泼尼松龙片对毒性弥漫性甲状腺肿(Graves病)患者免疫功能及甲状腺抗体水平的影响。方法:选取2018年9月-2020年11月笔者所在医院收治的97例Graves病患者,按照随机数字表法将其分为对照组(48例)和观察组(49例)。对照组予以泼尼松龙片治疗,观察组在对照组的基础上联合百令胶囊治疗。两组均连续治疗3个月。比较两组临床疗效,治疗前后免疫功能和甲状腺抗体水平变化。结果:观察组治疗总有效率为75.51%,高于对照组的54.17%,差异有统计学意义(P<0.05)。治疗后,两组血清CD4^(+)、CD4^(+)/CD8^(+)水平及血清TRAb、TGAb、TPOAb水平均较治疗前显著降低,且观察组均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血清CD8^(+)水平均较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:百令胶囊联合泼尼松龙片治疗Graves病的效果显著,可调节患者的免疫功能,降低甲状腺抗体水平。
Objective:To investigate the effect of Bailing Capsule combined with Prednisolone Tablet on immune function and thyroid antibody level in patients with toxic diffuse goiter(Graves disease).Method:A total of 97 patients with Graves disease admitted in our hospital from September 2018 to November 2020 were selected and divided into the control group(48 cases)and the observation group(49 cases)according to random number table method.The control group was treated with Prednisolone Tablet,and the observation group was combined with Bailing Capsule on the basis of the control group.Both groups were treated continuously for 3 months.The clinical efficacy,immune function and thyroid antibody level before and after treatment were compared between the two groups.Result:The total effective rate of the observation group was 75.51%,which was higher than 54.17%of the control group,and the difference was statistically significant(P<0.05).After treatment,serum CD4^(+),CD4^(+)/CD8^(+) levels and serum TRAB,TGAb and TPOAb levels in both groups were lower than those before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,serum CD8^(+) levels in both groups were higher than those before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05).Conclusion:Baling Capsule combined with Prednisolone Tablet has a significant effect in the treatment of Graves disease,which can regulate the immune function of patients,reduce the thyroid antibody level.
作者
魏兆丽
贾晓斌
WEI Zhaoli;JIA Xiaobin(Binzhou Central Hospital,Huimin 251700,China;不详)
出处
《中外医学研究》
2021年第20期58-60,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
