摘要
目的:探讨肾益康胶囊联合氯沙坦钾对慢性肾炎患者肾功能、血清白蛋白(ALB)水平的影响。方法:选取2018年2月-2020年10月在本院接受治疗的慢性肾炎患者94例,按照随机数字表法分成观察组和对照组各47例,对照组给予单纯氯沙坦钾治疗,观察组在此基础上加用肾益康胶囊治疗,对两组临床疗效、临床症状、肾功能及血清ALB水平进行比较。结果:观察组治疗总有效率明显高于对照组(P<0.05);两组治疗后中医症候积分均明显降低(P<0.05),且观察组积分明显低于对照组(P<0.05);两组治疗后血清肌酐(Scr)、尿蛋白水平明显降低(P<0.05),24 h尿量、肾小球滤过率(eGFR)水平明显提高(P<0.05),观察组Scr、尿蛋白水平明显低于对照组(P<0.05),24 h尿量、eGFR水平明显高于对照组(P<0.05);两组治疗后ALB水平明显提高(P<0.05),观察组ALB水平明显高于对照组(P<0.05)。结论:采用肾益康胶囊联合氯沙坦钾治疗慢性肾炎患者,可有效改善患者肾功能,提高ALB水平,进一步提高治疗有效率,值得临床推广。
Objective:To investigate the effect of Shenyikang Capsule combined with Losartan Potassium on renal function and serum albumin(ALB)level in patients with chronic glomerulonephritis.Method:A total of 94 patients with chronic glomerulonephritis treated in our hospital from February 2018 to October 2020 were randomly divided into observation group(n=47)and control group(n=47).The control group was treated with Losartan Potassium.On this basis,the observation group was treated with Shenyikang Capsule,and the clinical efficacy,clinical symptoms,renal function and serum ALB levels of the two groups were compared.Result:The total effective rate of the observation group was significantly higher than that of the control group(P<0.05),and the TCM syndrome scores of the two groups decreased significantly after treatment(P<0.05),and the score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the levels of serum creatinine(Scr)and urinary protein in the two groups decreased significantly(P<0.05),while the levels of 24-hour urine volume and glomerular filtration rate(eGFR)increased significantly(P<0.05).The levels of Scr and urinary protein in the observation group were significantly lower than those in the control group(P<0.05),while the levels of 24-hour urine volume and eGFR in the observation group were significantly higher than those in the control group(P<0.05).After treatment,the level of ALB was significantly higher(P<0.05),the level of ALB in the observation group was significantly higher than that in the control group(P<0.05).Conclusion:Shenyikang Capsule combined with Losartan Potassium in the treatment of chronic glomerulonephritis can effectively improve the renal function,increase the level of ALB and further improve the effective rate of treatment,which is worthy of clinical promotion.
作者
黄大雄
李林峰
HUANG Daxiong;LI Linfeng(People’s Hospital of Xishui County,Xishui 438200,China;不详)
出处
《中外医学研究》
2021年第21期128-130,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
慢性肾炎
肾益康胶囊
氯沙坦钾
肾功能
血清白蛋白
Chronic glomerulonephritis
Shenyikang capsule
Losartan potassium
Renal function
Serum albumin
