摘要
目的:观察健脾汤联合蒙脱石散治疗脾虚型小儿慢性腹泻的临床疗效及其对体液免疫功能、肠黏膜屏障功能及炎性因子水平的影响。方法:将154例脾虚型慢性腹泻患儿按照随机数字表法分为治疗组80例与对照组74例。对照组患儿给予蒙脱石散治疗,治疗组在对照组的基础上给予自拟健脾汤治疗。比较两组患儿治疗前后临床症状积分、体液免疫功能[分泌型免疫球蛋白A(secretory immunoglobulin A,sIgA)、免疫球蛋白A(immunoglobulin A,IgA)、免疫球蛋白G(immunoglobulin G,IgG)]、肠黏膜屏障功能[内毒素、D-乳酸、二胺氧化酶(diamine oxidase,DAO)]及炎性因子[白细胞介素(interleukin,IL)-6、IL-10及肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]改善情况。结果:两组患儿治疗后临床症状积分低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。两组患儿治疗后sIgA、IgA、IgG水平高于本组治疗前,且治疗后治疗组高于对照组,差异具有统计学意义(P<0.05)。两组患儿治疗后内毒素、DAO、D-乳酸、IL-6、IL-10、TNF-α水平低于本组治疗前,且治疗后治疗组低于对照组,差异具有统计学意义(P<0.05)。结论:自拟健脾汤联合蒙脱石散治疗脾虚型小儿慢性腹泻,可改善患儿临床症状,提高体液免疫功能,恢复肠黏膜屏障功能,降低炎性因子水平。
Objective:To observe the clinical curative effect of Spleen-Fortifying Decoction combined with Smectite Powder on children with chronic diarrhea with spleen deficiency syndrome and its influence on humoral immune function,intestinal mucosal barrier function and inflammatory factors.Methods:A total of 154 children with chronic diarrhea with spleen deficiency syndrome were randomly divided into the control group and the treatment group,with 80 cases and 74 cases respectively.The control group was treated with Smectite Powder,while the treatment group was treated with self-made Spleen-Fortifying Decoction on the basis of the control group.The improvement of the clinical symptom score,humoral immune functions[including secretory immunoglobulin A(sIgA),immunoglobulin A(IgA),immunoglobulin G(IgG)]and intestinal mucosal barrier functions[including endotoxin,D-lactate,diamine oxidase(DAO)],and inflammatory factors[including interleukin(IL-6),IL-10 and tumor necrosis factor-α(TNF-α)]were compared between the two groups before and after treatment.Results:After treatment,the clinical symptom score of the two groups was lower than that of the same group before treatment,and the clinical symptom score of the treatment group was lower than that of the control group,the difference was statistically significant(P<0.05).The levels of sIgA,IgA and IgG in the two groups after treatment were higher than those of the same group before treatment,and the above indexes of the treatment group after treatment were higher than those of the control group,and all the differences were statistically significant(P<0.05).After treatment,endotoxin,DAO,D-lactic acid,IL-6,IL-10 and TNF-αwere lower than those of the same group before treatment,and the above indexes of the treatment group after treatment were lower than those of the control group,and all the differences were statistically significant(P<0.05).Conclusion:In terms of children with chronic diarrhea with spleen deficiency syndrome,self-made Spleen-Fortifying Decoction combined with Smectite Powder can improve the clinical symptoms,humoral immune function,recover intestinal mucosal barrier function and reduce the level of inflammatory factors.
作者
葛生虎
许小敏
郭军雄
GE Sheng-hu;XU Xiao-min;GUO Jun-xiong(Medical College of Hexi University,Zhangye,Gansu,China,734000;Silk Road Traditional Chinese Medicine Research Center of Hexi University,Zhangye,Gansu,China,734000)
出处
《河南中医》
2021年第8期1206-1209,共4页
Henan Traditional Chinese Medicine
基金
国家自然科学基金项目(81660759)
河西学院科研创新与应用校长基金项目(XZ2018019)。
关键词
小儿慢性腹泻
脾虚证
健脾汤
蒙脱石散
中西医结合疗法
chronic diarrhea in children
spleen deficiency syndrome
Spleen-Fortifying Decoction
Smectite Powder
integrated traditional Chinese and Western medicine therapy
