摘要
肝窦内皮细胞(LSECs)在维系肝窦微循环以维持肝脏稳态中发挥了积极作用,同时在肝损伤修复中又介导了肝再生和纤维化平衡。急性肝损伤后,LSECs是肝脏修复性再生的调控者,而慢性肝损伤时,异常激活的LSECs促进了肝纤维化的发展。本文就近年来LSECs介导肝再生与纤维化平衡的研究进展综述,旨在为LSECs靶向治疗肝纤维化和促进肝再生的研究提供新思路。
Liver sinusoidal endothelial cells(LSECs)play a positive role in maintaining microcirculation of the liver to achieve liver homeostasis,and they also mediate a balance between regeneration and fibrosis in the process repair of liver injury.After acute liver injury,LSECs are the regulators of liver regeneration,while in chronic injury,abnormally activated LSECs promote development of liver fibrosis.In this paper,we summarized the recent progress in research on the balance between LSECs-mediated liver regeneration and fibrosis,with the aim to provide new ideas in treating liver fibrosis and promoting liver regeneration by targeting LSECs.
作者
袁博
瞿思铭
黄汉飞
曾仲
Yuan Bo;Qu Siming;Huang Hanfei;Zeng Zhong(Organ Transplantation Center,First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2021年第7期545-548,共4页
Chinese Journal of Hepatobiliary Surgery
基金
云南省教育厅科学研究基金(2020Y0121)
国家自然科学基金(81760119,81960124)。
关键词
内皮细胞
肝切除术
肝再生
肝纤维化
Endothelial cells
Hepatectomy
Liver regeneration
Liver fibrosis
