摘要
目的探讨和血柔肝方联合熊去氧胆酸胶囊治疗原发性胆汁性胆管炎(Primary biliary cholangitis,PBC)的临床疗效。方法选取2017年1月—2020年1月收治的PBC患者100例,按随机数字表法分为对照组(50例)和治疗组(50例)。两组患者均给予常规保肝治疗,在此基础上对照组口服熊去氧胆酸胶囊,观察组在对照组基础上加用和血柔肝方治疗。对两组患者临床疗效、中医证候症状积分、肝功能指标、肝脏硬度值及安全性进行分析及比较。结果治疗组总有效率与对照组比较明显升高,差异有统计学意义(P<0.05)。治疗后治疗组中医症状积分与对照组比较明显降低,差异有统计学意义(P<0.05)。治疗后治疗组总胆红素(Total bilirubin,TBil)、碱性磷酸酶(Alkaline phosphatase,ALP)、谷氨酰转移酶(Glutamyltransferase,GGT)、天门冬氨酸氨基转移酶(Aspartate aminotransferase,AST)、丙氨酸氨基转移酶(Alanine aminotransferase,ALT)水平与对照组比较明显下降,差异有统计学意义(P<0.05)。治疗后治疗组肝脏硬度值与对照组比较明显下降,差异有统计学意义(P<0.05)。治疗组安全性与对照组比较,差异无统计学意义(P>0.05)。结论和血柔肝方联合熊去氧胆酸胶囊治疗PBC的效果显著,能明显改善患者临床症状、肝功能,且安全、可靠。
Objective To investigate the clinical efficacy of Hexuerougan Decoction combined with ursodeoxycholic acid capsules in the treatment of primary biliary cholangitis(PBC).Methods A total of 100 PBC patients admitted from January 2017 to January 2020 were selected and divided into a control group(50 cases)and a treatment group(50 cases)by a random number table.Both groups were given conventional liver protection treatment.On this basis,the control group received oral ursodeoxycholic acid capsules,and the observation group was treated with Hexue Rougan Decoction on the basis of the control group.The clinical efficacy,TCM syndrome symptom score,liver function index,liver hardness value and safety the two groups were analyzed and compared.Results The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05).After treatment,the TCM symptom score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,total bilirubin(TBil),alkaline phosphatase(ALP),glutamyltransferase(GGT),and aspartate aminotransferase(AST)in the treatment group,Alanine aminotransferase(ALT)was significantly decreased compared with the control group(P<0.05).After treatment,the liver stiffness value of the treatment group was significantly lower than that of the control group(P<0.05).There was no significant difference in safety between the treatment group and the control group(P>0.05).Conclusion Hexuerougan Decoction combined with ursodeoxycholic acid capsules is effective in the treatment of PBC,which can significantly improve the clinical symptoms and liver function of patients,and is safe and reliable.
作者
马燕
徐强
宁忠慧
王艳
MA Yan;XU Qiang;NING Zhong-hui;WANG Yan(Department of Liver Diseases,Hospital of Traditional Chinese Medicine of Xinjiang Uygur Autonomous Region,Urumqi Xinjiang 830000;Department of Integrated Traditional Chinese and Western Medicine,Chengdu Fifth People′s Hospital,Chengdu Sichuan 611130)
出处
《世界中西医结合杂志》
2021年第7期1300-1303,共4页
World Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金委员会自助项目(81860808)。
关键词
原发性胆汁性胆管炎
和血柔肝方
熊去氧胆酸胶囊
肝功能
Primary Biliary Cholangitis
Hexue Rougan Decoction
Ursodeoxycholic Acid Capsules
Liver Function
