摘要
[目的]探讨急性髓系白血病(AML)患者血清ATP柠檬酸裂解酶(ACLY)表达水平及意义。[方法]选取2013年3月至2016年1月本院血液科收治的85例AML患者作为研究对象。通过RT-qPCR检测AML患者血清ACLY相对表达量,并分析血清ACLY水平与AML患者预后的关系。[结果]85例AML组患者3年生存率为28.24%(24/85)。死亡组AML患者血清ACLY相对表达量明显高于生存组[(1.72±0.37)vs(1.21±0.32),P<0.05]。ACLY评估AML预后不良的曲线下面积(AUC)为0.860。ACLY≥1.57的AML患者中位生存时间明显低于ACLY<1.57的AML患者[10(95%CI:8~16)个月vs 20(95%CI:10~31)个月,P<0.05]。Cox回归分析显示白细胞(WBC)计数、NCCN分层、骨髓原始粒细胞计数、完全缓解、ACLY与AML患者预后密切相关(P<0.05)。[结论]ACLY与AML预后关系密切,检测血清ACLY有助于评估AML患者预后情况。
[Objective]To investigate the expression and significance of serum ATP ceitrate lyase(ACLY)in patients with acute myeloid leukemia(AML).[Methods]F rom March 2013 to January 2016,85 patients with AML admitted to Hematology Department of our hospital were selected as the study subjects.Relative expressions of ACLY in serum of AML patients were detected by RT-q PCR,and the relationship between ACLY in serum and prognosis of AML patients was analyzed.[Results]The 3-year survival rate in 85 patients with AML was 28.24%(24/85).The relative expression of ACLY in serum of AML patients of death group was significantly higher than that of survival group AML patients[(1.72±0.37)vs(1.21±0.32),P<0.05].The AUC of the prognosis of AML assessed by ACLY was 0.860.The median survival time of AML patients with ACLY≥1.57 was significantly lower than that of AML.patients with ACLY<1.57[10(95%CI:8~16)months vs 20(95%CI:10~31)months,P<0.05].Univariate and multivariate Cox regression analysis showed that WBC(white blood cell),NCCN stratification,bone marrow primordial granulocyte count,complete remission,ACLY were closely related to the prognosis of AML.patients(P<0.05).[Conclusion]ACLY is closely related to the prognosis of AML.Detection of serum ACLY is helpful to evaluate the prognosis of AML patients.
作者
赵立丹
李荣芳
ZHAO Li-dan;LI Rong-fang(The Third Department of Geriatrics,Ninth Hospital of Xi'an,Xi'an 710054)
出处
《医学临床研究》
CAS
2021年第7期995-997,1001,共4页
Journal of Clinical Research
基金
陕西省自然科学基础研究计划项目(2020JQ-960)。
