摘要
牙周微生态失衡与牙周病以及许多全身系统性疾病关系密切。该文就牙周炎和牙周微生态失衡对高血压、动脉粥样硬化、心肌梗死、心肌肥厚、心力衰竭、脑卒中等心脑血管疾病的作用进行简要回顾。近年来牙周炎与这些心脑血管疾病之间的相关性已经被确立。目前牙周炎与高血压、动脉粥样硬化等部分心脑血管疾病之间的因果关系有一定的数据支持,但是尚需进一步完善,而且牙周炎与其他心脑血管疾病之间的因果关系尚待建立。已有一些数据支持牙周微生态失衡在除了脑卒中之外的其他几种心脑血管疾病中发挥重要作用,但是需要更加深入的研究来全面解析牙周微生态失衡的关键作用和机制。这些研究将为口腔疾病和心脑血管疾病的联合防控提供证据和思路。
Dysbiotic periodontal microbiota is closely associated with periodontal diseases and many systemic diseases. Here we briefly summarize the roles of periodontitis and dysbiotic periodontal microbiota in cardio-cerebrovascular diseases including hypertension, atherosclerosis, myocardial infarction, cardiac hypertrophy, heart failure and stroke. Correlations between periodontitis and these cardio-cerebrovascular diseases have been established in recent years. There are a few data supporting causal relationships between periodontitis and some cardio-cerebrovascular diseases such as hypertension and atherosclerosis, but more evidence is warranted. Furthermore, causal relationships between periodontitis and other cardio-cerebrovascular diseases are yet to be established. The importance of dysbiotic periodontal microbiota in cardio-cerebrovascular diseases except stroke has been supported by some data. However, research in more depth is required to fully comprehend the critical function and mechanism of dysbiotic periodontal microbiota in these diseases. Results of these studies will provide more evidence and ideas for joint prevention and control of oral diseases and cardio-cerebrovascular diseases.
作者
段胜仲
DUAN Shengzhong(Laboratory of Oral Microbiot.a and Systemic Diseases,Shanghai Ninth People’s Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)
出处
《口腔医学》
CAS
2021年第7期577-582,共6页
Stomatology
基金
国家自然科学基金重大项目(81991500,81991503)。
关键词
牙周微生态
牙周炎
心脑血管疾病
periodontal microbiota
periodontitis
cardio-cerebrovascular disease
