摘要
目的研究瑞格列奈片治疗老年糖尿病的治疗有效性和治疗安全性。方法选取该院于2019年3月—2020年2月期间内收治的老年糖尿病患者120例,用随机数字表法分组,各60例。对照组采用常规药物予以治疗,观察组在常规治疗的基础上增加瑞格列奈片治疗,比较治疗前后两组患者的血糖、血脂指标变化情况,并比较两组的不良反应发生率。结果治疗后两组的血糖和血脂水平较治疗前均明显改善,并且观察组治疗后的血糖和血脂水平显著优于对照组,差异有统计学意义(P<0.05);治疗后较治疗前相比,两组的同型半胱氨酸水平均有显著降低,且观察组治疗后的同型半胱氨酸显著低于对照组,差异有统计学意义(P<0.05);治疗后和治疗前相比两组的BMI指数均明显降低,而观察组治疗后的BMI指数明显小于对照组,差异有统计学意义(P<0.05);治疗期间观察组与对照组患者的不良反应发生率相比,差异无统计学意义(P>0.05)。结论采用瑞格列奈片治疗老年糖尿病兼具有效性和安全性,可改善患者的血糖和血脂水平,降低BMI指数和同型半胱氨酸水平,优势显著。
Objective To study the efficacy and safety of repaglinide tablets in the treatment of senile diabetes.Methods A total of 120 elderly diabetic patients admitted to the hospital from March 2019 to February 2020 were selected and divided into groups with a random number table,60 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with repaglinide tablets on the basis of conventional treatment.The changes in blood glucose and blood lipid indexes of the two groups of patients before and after treatment were compared,and the incidence of adverse reactions between the two groups was compared.Results After treatment,the blood glucose and blood lipid levels of the two groups were significantly improved compared to before treatment,and the blood glucose and blood lipid levels of the observation group after treatment were significantly better than those of the control group,and the difference was statistically significant(P<0.05);after treatment,compared with before treatment,the homocysteine levels of the two groups were significantly reduced,and the homocysteine of the observation group after treatment was significantly lower than that of the control group,and the difference was statistically significant(P<0.05);the BMI index of the two groups was compared after treatment and before treatment;the BMI index of the observation group after treatment was significantly lower than that of the control group,and the difference was statistically significant(P<0.05);there was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group during the treatment period(P>0.05).Conclusion The use of repaglinide tablets in the treatment of elderly diabetes is both effective and safe.It can improve the blood glucose and blood lipid levels of patients,and reduce the BMI index and homocysteine levels.It has significant advantages.
作者
梁光曦
卢锐锋
LIANG Guangxi;LU Ruifeng(Department of Pharmacy,Sanshui Hospital of Foshan Traditional Chinese Medicine Hospital,Foshan,Guangdong Province,528100 China)
出处
《糖尿病新世界》
2021年第10期74-77,共4页
Diabetes New World Magazine
关键词
瑞格列奈片
常规用药
老年糖尿病
血脂
血糖
治疗安全性
Repaglinide tablets
Conventional medications
Senile diabetes
Blood lipids
Blood glucose
Treatment safety
