摘要
目的:探讨干燥综合征(SS)患者Th1/Th2细胞因子表达水平与其中西医结合干预效果关系分析。方法:选取我院2016年5月至2018年6月收治的SS患者90例作为研究对象,根据干预方法不同分为中药组(n=30)、西药组(n=30)及中西药组(n=30),中药组给予养阴益气活血方治疗,西药组给予羟氯喹片治疗,中西药组为两种药物的结合治疗,另选取我院同期健康体检者30例为对照组,比较各组Th1、Th2相关细胞因子;采用干燥综合征疾病活动指数(ESSDAI)评估患者治疗前后疾病活动度;欧洲抗风湿联盟干燥综合征患者报告指数(ESSPRI)评估患者治疗前后主观干眼症状、疼痛、乏力等;采用Pearson线性相关检验分析SS患者Th1/Th2细胞因子表达水平与其中西医结合干预后ESSDAI、ESSPRI评分关系。结果:与对照组相比,各组患者治疗前Th1、Th2相关细胞因子水平均上升(P<0.05);治疗后各组患者IFN-γ、IL-2、IL-4、IL-10水平均较治疗前降低,且中西药组、中药组治疗后IFN-γ、IL-2、IL-4、IL-10水平均较西药组治疗后水平降低(P<0.05);治疗后,中西药组ESSDAI、ESSPRI评分均较中药组、西药组降低(P<0.05);Pearson线性相关性分析,SS患者Th1/Th2细胞因子表达水平与其中西医结合干预后ESSDAI、ESSPRI评分密切相关(P<0.05);结论:SS患者Th1/Th2细胞因子表达水平上调,西医结合干预可有效下调Th1/Th2细胞因子表达水平,其可能通过调节Th1/Th2免疫平衡达到治疗作用。
Objective:To explore the relationship between Th1/Th2 cytokine expression level and intervention effect of integrated traditional Chinese and Western medicine in patients with Sjogren’s syndrome(SS).Methods:90 patients with SS admitted to our hospital from May 2016 to June 2018 were selected as research objects.They were divided into Chinese medicine group(n=30),Western medicine group(n=30)and Chinese and Western medicine group(n=30),Chinese medicine group was treated with Yangyin Yiqi Huoxue recipe,Western medicine group was treated with hydroxychloroquine tablets,and Chinese and Western medicine group according to different intervention methods,in order to combine the two drugs,another 30 health check-up patients in our hospital at the same time were selected as control group.Th1 and Th2-related cytokines were compared in each group;EULAR SS disease activity index(ESSDAI)was used to evaluate the disease activity before and after treatment;and EULAR SS Patient Reported Index(ESSPRI)was used to evaluate the subjective dry eye symptoms,pain and fatigue before and after treatment.Pearson linear correlation analysis was used to determine relationship between Th1/Th2 cytokine expression level and ESSDAI and ESSPRI scores in patients with SS.Results:Compared with control group,levels of Th1 and Th2-related cytokines in each group increased before treatment(P<0.05);levels of IFN-γ,IL-2,IL-4 and IL-10 in each group decreased after treatment,and levels of IFN-γ,IL-2,IL-4 and IL-10 in Chinese and Western medicine group and traditional Chinese medicine group after treatment were all lower than Western medicine group after treatment(P<0.05).After treatment,scores of ESSDAI and ESSPRI in Chinese and Western medicine group were lower than those in Chinese medicine group and Western medicine group(P<0.05);Pearson linear correlation analysis showed that expressions of Th1/Th2 cytokines in SS patients was closely related to scores of ESSDAI and ESSPRI in Chinese and Western medicine group(P<0.05).Conclusion:Th1/Th2 cytokine expression level in SS patients is up-regulated,and the intervention of Western medicine can effectively reduce Th1/Th2 cytokine expression level,which may achieve therapeutic effect by regulating Th1/Th2 immune balance.
作者
马衍慧
章建峰
刘丽敏
MA Yan-Hui;ZHANG Jian-Feng;LIU Li-Min(Huzhou Hospital of Traditional Chinese Medicine,Zhejiang University of Traditional Chinese Medicine,Huzhou 313000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2021年第14期1757-1760,共4页
Chinese Journal of Immunology
关键词
干燥综合征
TH1/TH2
中西医结合
干预效果
关系
Sjogren’s syndrome
Th1/Th2
Combination of traditional Chinese and Western medicine
Intervention effect
Relation
