摘要
目的观察针刺八髎穴治疗冻胚移植患者宫腔积液的临床疗效及对胚胎移植结局的影响。方法选取2018年5月至2019年12月准备行冻胚移植并经阴道B超发现宫腔液区的240例患者。观察组120例患者在发现液区后开始进行针刺八髎穴治疗,每日1次,连续治疗至患者行胚胎移植术;其余120例患者为对照组并予中药治疗。观察两组患者治疗前后宫腔积液量的变化,比较两组胚胎移植结局。结果观察组治疗后宫腔分离最大前后径(APD)值明显小于治疗前(P<0.05),子宫内膜厚度大于治疗前(P<0.05);对照组治疗后的上述指标与治疗前比较,差异无统计学意义(P>0.05)。观察组患者移植取消率为16.7%、生化妊娠率为63.0%、临床妊娠率为57.0%、早期流产率为17.5%、宫外孕率为7.0%,对照组分别为33.3%、52.5%、47.5%、36.8%、21.1%,两组生化妊娠率和临床妊娠率比较差异无统计学意义(P>0.05),两组移植取消率、早期流产率和宫外孕率比较差异具有统计学意义(P<0.05)。结论针刺八髎穴可促进冻胚移植患者宫腔积液的吸收,改善胚胎移植结局,疗效优于中药治疗。
Objective To investigate the clinical efficacy of acupuncture at Baliao points for intrauterine effusion and its effect on embryo transfer outcome in patients with frozen embryo transfer.Method Two hundred and forty patients who would receive frozen embryo transfer and had intrauterine liquid area found by transvaginal B-ultrasound were enrolled from May 2018 to Dec.2019.One hundred and twenty patients in the observation group received acupuncture at Baliao points once daily after the liquid area was found.The treatment continued until the patients received embryo transfer.The other 120 patients in the control group received treatment of Chinese medicine.Intrauterine effusion volume was observed in the two groups before and after treatment.Embryo transfer outcomes were compared between the two groups.Result In the observation group,the maximum anterior-posterior diameter(APD)of uterine cavity was significantly smaller(P<0.05)and endometrial thickness was larger(P<0.05)after treatment compared with before.There were no statistically significant pre-/post-treatment differences in the above indicators in the control group(P>0.05).The embryo transfer cancellation rate,the biochemical pregnancy rate,the clinical pregnancy rate,the early miscarriage rate and the ectopic pregnancy rate were 16.7%,63.0%,57.9%,17.5%and 7.0%,respectively,in the observation group of patients and 33.3%,52.5%,47.5%,36.8%and 21.1%,respectively,in the control group.There were no statistically significant differences in the biochemical pregnancy rate and the clinical pregnancy rate(P>0.05)and statistically significant differences in the embryo transfer cancellation rate,the early miscarriage rate and the ectopic pregnancy rate(P<0.05)between the two groups.Conclusion Acupuncture at Baliao pointscan can promote the absorption of intrauterine effusion and improve embryo transfer outcome in patients with frozen embryo transfer.Its therapeutic effect is better than that of treatment with Chinese medicine.
作者
周雪
李秀玲
苏雁
ZHOU Xue;LI Xiu-ling;SU Yan(Women’s Hospital of Nanjing Medical University(Nanjing Maternity and Child Health Care Hospital),Nanjing 210001,China)
出处
《上海针灸杂志》
2021年第8期993-997,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
国家自然科学基金项目(81971386)。
关键词
针刺疗法
不育
女性
宫腔积液
冷冻胚胎
胚胎移植
穴
八髎
子宫内膜厚度
Acupuncture therapy
Infertility,Female
Intrauterine effusion
Frozen embryo
Embryo transfer
Points,Baliao
Endometrial thickness
