摘要
目的探讨使用血管加压素对心血管外科术后患者预后的影响。方法回顾性分析重症患者数据库(MIMIC-Ⅲ)中心血管外科术后患者的临床资料,采用COX回归分析心血管外科术后使用血管加压素对患者预后的影响,结局指标为30 d全因死亡率、1年全因死亡率及长期全因死亡率。结果该研究共纳入6824例心血管外科手术患者,其中使用血管加压素的患者有364例,其30 d全因死亡率、1年全因死亡率及长期全因死亡率均明显高于未使用血管加压素的患者(P<0.001)。COX回归分析显示,血管加压素的使用与心血管外科术后30 d全因死亡率[HR=7.229,95%CI(4.351,12.023),P<0.001]、1年全因死亡率[HR=3.322,95%CI(2.379,4.637),P<0.001]及长期全因死亡率[HR=2.457,95%CI(1.932,3.141),P<0.001]的增加明显相关。结论血管加压素的使用可明显增加心血管外科术后患者的死亡风险。
Objective To investigate the effect of vasopressin on the postoperative prognosis of the patients with cardiovascular surgery.Methods The clinical data of the postoperative patients with cardiovascular surgery in the critical illness patients database(MIMIC-Ⅲ)were retrospectively analyzed.The COX regression analysis was used to analyze the effect of vasopressin on the patient′s prognosis after cardiovascular surgery.The outcome indicators were 30 d,1-year and long-term all-cause mortalities.Results A total of 6824 patients with cardiovascular surgery were included in this study.Among them,364 cases used vasopressin.The 30 d,1-year and long-term all-cause mortalities of the patients treated with vasopressin were significantly higher than those without vasopressin use(P<0.001).The COX regression analysis showed that the vasopressin use was significantly associated with the increase of 30 d all-cause mortality[HR=7.229,95%CI(4.351,12.023),P<0.001],1-year all-cause mortality[HR=3.322,95%CI(2.379,4.637),P<0.001]and long-term all-cause mortality[HR=2.457,95%CI(1.932,3.141),P<0.001]in the patients with cardiovascular surgery.Conclusion The vasopressin use can significantly increase the risk of death in postoperative patients with cardiovascular surgery.
作者
李明辉
王晓伟
李京杭
LI Minghui;WANG Xiaowei;LI Jinghang(Department of Cardiovascular Surgery,First Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China)
出处
《重庆医学》
CAS
2021年第15期2560-2563,共4页
Chongqing medicine
基金
国家自然科学基金面上项目(81773445)。
