摘要
目的分析连续性血液净化治疗(CBP)对重症急性呼吸窘迫综合征的临床疗效。方法80例重症急性呼吸窘迫综合征患者,随机分为观察组与参照组,各40例。参照组患者行常规方法治疗,观察组在常规治疗基础上行CBP。对比两组治疗前及治疗1周后的氧合指数(PaO2/FiO2)、急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、炎症指标水平及临床疗效。结果治疗1周后,两组PaO2/FiO2、APACHEⅡ评分均优于本组治疗前,且观察组PaO2/FiO2为(300.15±73.48)mm Hg(1 mm Hg=0.133 kPa),APACHEⅡ评分为(8.36±2.44)分,均优于参照组的(233.42±95.36)mm Hg、(10.37±3.85)分,差异均有统计学意义(P<0.05)。治疗1周后,两组白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)、白细胞计数(WBC)、C反应蛋白(CRP)水平均低于本组治疗前,且观察组低于参照组,差异均有统计学意义(P<0.05)。观察组总有效率95.0%高于参照组的75.0%,差异有统计学意义(P<0.05)。结论对于重症急性呼吸窘迫综合征患者联合应用CBP效果更佳。
Objective To analyze the clinical efficacy of continuous blood purification(CBP)on severe acute respiratory distress syndrome.Methods A total of 80 patients with severe acute respiratory distress syndrome were randomly divided into observation group and reference group,with 40 cases in each group.The reference group was treated with conventional therapy,and the observation group was treated with CBP based on conventional therapy.The oxygenation index(PaO2/FiO2),acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score,inflammation index level and clinical efficacy were compared between the two groups.Results After 1 week of treatment,the PaO2/FiO2 and APACHEⅡ score of the two groups were better than those before treatment,and the PaO2/FiO2(300.15±73.48)mm Hg(1 mm Hg=0.133 kPa)and APACHEⅡ score(8.36±2.44)points of the observation group were better than(233.42±95.36)mm Hg and(10.37±3.85)points of the reference group.All the difference was statistically significant(P<0.05).After 1 week of treatment,the interleukin 6(IL-6),tumor necrosis factor-α(TNF-α),white blood cell count(WBC),C-reactive protein(CRP)levels of the two groups were lower than those before treatment,and the observation group was lower than the reference group.All the difference was statistically significant(P<0.05).The total effective rate of the observation group was 95.0%,which was higher than 75.0% of the reference group,and the difference was statistically significant(P<0.05).Conclusion CBP is effective for patients with severe acute respiratory distress syndrome.
作者
胡漫林
钟天顺
邬君生
HU Man-lin;ZHONG Tian-shun;WU Jun-sheng(Department of Critical Care Medicine,Yangjiang Hospital of Traditional Chinese Medicine,Yangjiang 529500,China)
出处
《中国现代药物应用》
2021年第15期39-41,共3页
Chinese Journal of Modern Drug Application
关键词
连续性血液净化
重症急性呼吸窘迫综合征
临床疗效
Continuous blood purification
Severe acute respiratory distress syndrome
Clinical efficacy
