摘要
目的探讨中性粒细胞计数与淋巴细胞计数比值(NLR)在成人急性细菌性上呼吸道感染中的预测价值及发病因素分析。方法方便选取2019年8月—2020年10月该院门急诊就诊的成人急性上呼吸道感染69例作为研究对象,根据WBC和/N%检测结果分为升高组和未升高组,将同期体检健康者35名作为观察组,比较3组的中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、中性粒细胞计数/淋巴细胞计数(NLR)、中性粒细胞百分比(N%)、淋巴细胞百分比(L%)检测水平。应用ROC曲线,计算曲线下面积(AUC),评价NLR对成人急性细菌性上呼吸道感染的预测价值。结果升高组的NEU、NLR、N%分别为8.10(6.45,9.70)×10^(9)/L、5.84(3.82,7.68)、77.30(71.95,83.65)%,显著高于未升高组的3.55(2.70,5.50)×10^(9)/L、1.92(1.09,2.80)、59.55(47.40,66.80)%和观察组的3.90(3.20,4.70)×10^(9)/L、1.78(1.46,2.14)、59.10(54.80,63.10)%,升高组的LYM、L%分别为1.49(1.09,1.97)×10^(9)/L、13.90(10.55,19.05)%,低于未升高组的2.23(1.57,2.68)×10^(9)/L、30.70(23.68,43.78)%和观察组的2.14(1.77,2.60)×10^(9)/L、33.90(29.70,37.60)%,差异有统计学意义(P<0.05)。ROC曲线显示NLR为3.21是预测成人急性细菌性上呼吸道感染的最佳截断值,其敏感度、特异度分别为83.8%、90.6%。结论微生态失调、炎性反应紊乱及免疫力下降是成人急性细菌性上呼吸道感染的发病因素。NRL对细菌性感染有较高的诊断价值,有利于指导临床早期使用抗生素。
Objective To explore the predictive value of the ratio of neutrophil count to lymphocyte count(NLR)in adult acute bacterial upper respiratory tract infection and the analysis of pathogenic factors.Methods A total of 69 adult acute upper respiratory tract infections in the hospital from August 2019 to October 2020 were conveniently selected as the research objects.According to the WBC and/N%test results,they were divided into an elevated group and a non-elevated group,and physical examinations during the same period 35 healthy subjects served as a observation group to compare the neutrophil count(NEU),lymphocyte count(LYM),neutrophil count/lymphocyte count(NLR),and percentage of neutrophils(N%),lymphocyte percentage(L%)in the three groups,detection level.The ROC curve was used to calculate the area under the curve(AUC)to evaluate the predictive value of NLR for adult acute bacterial upper respiratory tract infections.Results The NEU,NLR,and N%of the elevated group were 8.10(6.45,9.70)×10^(9)/L,5.84(3.82,7.68),and 77.30(71.95,83.65)%,which were significantly higher than the 3.55(2.70,5.50)×10^(9)/L,1.92(1.09,2.80),59.55(47.40,66.80)%of the non-elevated group,and observation group 3.90(3.2,4.70)×10^(9)/L,1.78(1.46,2.14),59.10(54.80,63.10)%,the LYM and L%of the elevated group were 1.49(1.09,1.97)×10^(9)/L,13.90(10.55,19.05)%,which were lower than 2.23(1.57,2.68)×10^(9)/L,30.70(23.68,43.78)%of the non-elevated group and 2.14(1.77,2.60)×10^(9)/L,33.90(29.70,37.60)%of the observation group,the difference was statistically significant(P<0.05).The ROC curve shows that an NLR of 3.21 was the best cut-off value for predicting adult acute bacterial upper respiratory tract infection,and its sensitivity and specificity were 83.8%and 90.6%,respectively.Conclusion Microecological disorders,inflammatory response disorders and decreased immunity are the pathogenic factors of acute bacterial upper respiratory tract infections in adults.NRL has a high diagnostic value for bacterial infections and is helpful to guide the early clinical use of antibiotics.
作者
钱春花
刘岚
贲如银
谈海琴
QIAN Chunhua;LIU Lan;BEN Ruyin;TAN Haiqin(Department of General Internal Medicine,Affiliated Tumor Hospital of Nantong University,Nantong,Jiangsu Province,226006 China;Physical Examination Center,Affiliated Tumor Hospital of Nantong University,Nantong,Jiangsu Province,226006 China)
出处
《中外医疗》
2021年第18期65-68,共4页
China & Foreign Medical Treatment
