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THA术后感染CRP、ESR及D-二聚体水平变化研究 被引量:1

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摘要 目的探讨全髋关节置换术(THA)术后慢性假体周围感染C反应蛋白(CRP)、红细胞沉降率(ESR)及D-二聚体水平变化及其诊断价值。方法选定2015年3月至2020年3月在医院进行THA手术的70例患者作为研究对象,按照是否出现假体周围感染分为感染组10例,非感染组60例。对比分析两组患者于手术后CRP、ESR及D-二聚体水平变化情况,并应用受试者工作特性曲线ROC分析CRP、ESR及D-二聚体的敏感度和特异性,评估CRP、ESR及D-二聚体对诊断THA术后慢性假体周围感染的临床价值。结果感染组患者术后CRP、ESR及D-二聚体水平均明显高于非感染组,差异有统计学意义(P<0.001);经ROC曲线分析,CRP的灵敏度为84.61%、特异度为64.81%、AUC面积为0.718、截断值为3.17mg/mL,ESR的的灵敏度为73.08%、特异度为90.47%、AUC面积为0.717、截断值为32mm/h,D-二聚体的灵敏度为80.77%、特异度为79.63%、AUC面积为0.911、截断值为1180ng/ml,患者术后CRP、ESR及D-二聚体水平均能较好诊断出慢性假体周围感染(P<0.001);患者CRP、ESR、D-二聚体及三者联合检测应用价值发现,CRP、ESR、D-二聚体三者联合检测时的敏感度为88.90%,特异度为92.31%,均明显高于CRP、ESR、D-二聚体单独检测值。结论对THA患者术后进行CRP、ESR及D-二聚体水平检测,对THA术后慢性假体周围感染临床诊断具有重要意义。
出处 《浙江创伤外科》 2021年第4期642-644,共3页 Zhejiang Journal of Traumatic Surgery
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