摘要
目的:观察肝失疏泄对化疗后三阴性乳腺癌患者认知功能与神经内分泌功能水平的影响。方法:对河南中医药大学第一附属医院肿瘤科门诊和病房就诊的化疗后三阴性乳癌患者采用艾森克人格问卷进行调查评估,(EPQ)N维度量表评估筛选情绪稳定与不稳定的患者,并按照同性别、同年龄段、同文化程度进行1∶1匹配。采用蒙特利尔量表(MoCA)评估认知功能,采用肝气郁结量表观察肝气郁结程度,采用酶联免疫吸附法检测神经内分泌水平。结果:情绪不稳定组的认知功能明显下降(P<0.001),情绪不稳定组患者在语言、定向得分、注意力、视空间与执行、延迟回忆方面显著低于情绪稳定组(P<0.001),两组间抽象、命名得分无统计学意义(P>0.05),肝气郁结证症状程度计分量表情绪不稳定组评分高于情绪稳定组(P<0.001)。情绪不稳定组ACTH、NE的水平较情绪稳定组显著升高(P<0.001);GC水平相近,两组间比较无统计学意义(P>0.05)。结论:长期情绪调节不良,肝失疏泄可导致化疗后三阴性乳腺癌患者认知功能下降,而神经内分泌功能的改变可能是其机制之一。
Objective:To observe the effect of Liver failing in controlling dispersion on cognitive function and neuroendocrine function in patients with triple negative breast cancer after chemotherapy. Methods:The emotional stability and instability of the patients with triple negative breast cancer after chemotherapy were assessed by Eysenck Personality Questionnaire(EPQ) N-dimension scale and matched 1∶1 according to the same sex,age and education level. The Montreal Scale(MoCA)was used to assess the cognitive function. The degree of Liver-qi stagnation of the two groups was observed by the Liver-Qi Depression Scale. The levels of neuroendocrine function were detected by enzyme-linked immunosorbent assay(ELISA)in the two groups. Results:The cognitive function of the emotional instability group decreased significantly(P < 0. 001). The scores of visual space and execution force,attention,language,delayed recall and orientation decreased significantly in the emotional instability group(P < 0. 001). There was no significant difference in abstract and naming scores between the two groups(P > 0. 05). The scores of the symptoms of Liver-qi stagnation were higher in the emotional instability group than those in the emotional stability group(P < 0. 001). The levels of ACTH and NE in the emotional instability group were significantly higher than those in the emotional stability group(P < 0. 001). There was no significant difference in the level of GC between the two groups(P > 0. 05). Conclusion:Long-term poor emotional regulation of Liver failing in controlling dispersion can lead to cognitive decline in patients with triplenegative breast cancer after chemotherapy,and the change of neuroendocrine function may be one of the mechanisms.
作者
王冰
孙士玲
周思雨
关徐涛
WANG Bing;SUN Shiling;ZHOU Siyu;GUAN Xutao(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan Workers Hospital,Zhengzhou 450000,China)
出处
《中医药信息》
2021年第8期41-46,共6页
Information on Traditional Chinese Medicine
基金
国家自然科学基金项目(81804196)
教育部中国博士后基金项目(2017M612407)
国家中医临床研究基地河南省中医药科学研究专项课题(2019JDZX014,2018JDZX023)
河南中医药科学研究专项课题(20-21ZY1010,20-21ZY2106)
河南中医药大学苗圃基金(MP2020-14)。
关键词
肝失疏泄
化疗后三阴性乳腺癌
认知功能
神经内分泌功能
Liver failing in controlling dispersion
Triple negative breast cancer after chemotherapy
Cognitive function
Neuroendocrine function
