摘要
目的评估帕瑞昔布钠和氟比洛芬酯在骨折术后的临床镇痛效果。方法选择2019年10月至2020年6月安庆市第二人民医院骨折术后病人,分为氟比洛芬酯组和帕瑞昔布钠组。氟比洛芬酯组采用50 mg氟比洛芬酯注射液,帕瑞昔布钠组采用40 mg帕瑞昔布钠注射液,均静脉滴注,一日1~2次。采用视觉模拟评分法(VAS)对病人进行疼痛评分,比较两组病人术后VSA评分、不良反应发生及药物治疗费用。结果氟比洛芬酯组45例,帕瑞昔布钠组55例。氟比洛芬酯组镇痛药物治疗(3.80±1.28)d,较帕瑞昔布钠组(4.56±2.04)d明显缩短(P=0.026)。治疗12 h氟比洛芬酯组VAS评分(4.20±0.73)分,明显低于帕瑞昔布钠组的(5.75±1.31)分(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。氟比洛芬酯组镇痛药物总费用(360.44±152.88)元,较帕瑞昔布钠组的(502.38±234.77)元明显降低(P=0.001)。结论氟比洛芬酯可有效缓解骨折术后病人疼痛,降低病人治疗费用,优于帕瑞昔布钠。
Objective To evaluate the analgesic effects of parecoxib sodium and flurbiprofen axetil after fracture surgery.Methods The patients who underwent fracture surgery in The Second People’s Hospital of Anqing from October 2019 to June 2020 were selected and assigned into flurbiprofen axetil group and parecoxib sodium group.Flurbiprofen axetil group was treated with 50 mg flurbiprofen axetil for Ⅳ infusion once or twice daily,and parecoxib sodium group was treated with 40 mg parecoxib sodium for Ⅳ infusion once or twice daily.The visual analogue scale(VAS) was used to score the patients,and the VS A scores,adverse reactions,and drug treatment costs of the two groups of patients were compared.Results A total of 45 patients were included in the flurbiprofen axetil group and 55 patients in the parecoxib sodium group.The days of analgesic medication in the flurbiprofen axeti group were significantly shorter than those in the parecoxib sodium group [(3.80±1.28) d vs.(4.56±2.04) d,P=0.026].The VAS score of the flurbiprofen axetil group 12 h after treatment was significantly lower than that of the parecoxib sodium group [(4.20±0.73) vs.(5.75±1.31),P<0.05].There was no significant difference in adverse reactions between the two groups(P>0.05).The total cost of analgesic drugs in the flurbiprofen axetil group was significantly lower than that in the parecoxib sodium group [(360.44±152.88) yuan vs.(502.38±234.77) yuan,P=0.001].Conclusion Flurbiprofen axetil can effectively relieve the pain of patients after fracture surgery and reduce the cost of treatment,which is better than parecoxib sodium.
作者
王谋江
程翩翩
王鹏
陆平生
唐举峰
杨小四
WANG Moujiang;CHENG Pianpian;WANG Peng;LU Pingsheng;TANG Jufeng;YANG Xiaosi(Department of Pharmacy,The Second People's Hospital of Anqing,Anqing,Anhui 246003,China;Department of Orthopaedics,The Second People's Hospital of Anqing,Anqing,Anhui 246003,China;Department of Basic Medicine,Anqing Medical College,Anqing,Anhui 246003,China)
出处
《安徽医药》
CAS
2021年第9期1874-1877,共4页
Anhui Medical and Pharmaceutical Journal
基金
2019年度安徽高校自然科学研究项目(KJ2019A1234)。
关键词
镇痛
输注
静脉内
骨折
疼痛
手术后
帕瑞昔布钠
氟比洛芬酯
数字评分法
Analgesia
Infusions,intravenous
Fractures,bone
Pain,postoperative
Parecoxib sodium
Flurbiprofen axetil
Visual analogue scale
